Skip to main content

Table 3 Characteristics of individuals stratified by APOE genotypes

From: Sex-specific interaction between APOE genotype and carbohydrate intake affects plasma HDL-C levels: the Strong Heart Family Study

 

Males

P e

Females

P e

Without e4 (n=236)

With e4 (n=85)

Without e4 (n=329)

With e4 (n=94)

Trait

LS-Mean (SE)

LS-Mean (SE)

 

LS-Mean (SE)

LS-Mean (SE)

 

 Age (year)

39.3 (0.9)

36.5 (1.6)

0.12

40.6 (1.3)

39.5 (1.8)

0.51

 BMIa

32.3 (0.9)

34.6 (1.2)

0.009

33.8 (1.2)

35.6 (1.4)

0.12

 BFb (%)

30.9 (1.1)

33.3 (1.3)

0.012

42.9 (1.2)

44.1 (1.4)

0.18

 FG (mg/dl)

115.9 (4.1)

122.8 (6.3)

0.24

130.0 (7.2)

126.9 (8.8)

0.79

 FI (mIU/l)

28.8 (4.2)

33.4 (5.1)

0.042

24.8 (1.4)

26.3 (2.7)

0.25

 Diabetes status

  Diabetic (%)

18.6

26.0

0.17

25.2

23.4

0.63

  IGTc (%)

10.6

7.0

0.33

6.4

6.4

0.99

Lipids

 TC (mg/dl)

180.0 (3.6)

178.8 (4.9)

0.74

176.0 (3.7)

175.6 (4.8)

0.92

 HDL (mg/dl)

43.7 (1.7)

39.5 (2.1)

0.029

45.3 (1.6)

41.6 (1.9)

0.012

 HDL-AHA

  <40 (%)

51.7

61.2

0.13

41.6

53.4

0.004

  41–59 (%)

37.3

35.2

0.56

44.4

40.4

0.15

  >60 (%)

10.6

3.5

0.11

13.4

6.4

0.024

 LDL (mg/dl)

115.4 (3.0)

118.6 (4.1)

0.44

109.9 (2.2)

113.2 (3.2)

0.29

 TG (mg/dl)

130.2 (7.3)

141.8 (10.1)

0.10

126.8 (5.0)

121.4 (7.7)

0.62

 APOA-1 (mg/dl)

1.33 (0.03)

1.21 (0.03)

<0.001

1.38 (0.04)

1.29 (0.04)

0.004

Dietaryd

 Total (Kcal)

2,373 (85)

2,112 (128)

0.075

1,914 (50)

1,816 (91)

0.65

  Carb (%)

50.2 (1.0)

50.4 (1.5)

0.88

52.2 (0.8)

53.2 (1.3)

0.45

  Prot (%)

14.3 (0.4)

15.0 (0.6)

0.46

14.0 (0.3)

13.8 (0.5)

0.67

  Fat (%)

34.3 (0.9)

32.9 (1.3)

0.28

34.4 (0.6)

33.8 (1.0)

0.57

  1. Genotypes pooled into two groups: those without e4 and those with e4 allele. P values indicate significant differences between genotypes, within sex
  2. aBMI = kg/m2
  3. bBF = body fat
  4. cIGT = impaired glucose tolerance
  5. dDietary traits = percent of total daily Kcal intake
  6. eSignificant P ≤ 0.05 in generalized linear mixed models (continuous outcomes) or generalized estimating equations (categorical outcomes), which controlled for the correlation among members in the same pedigrees
  7. FG = fasting glucose, FI = fasting insulin