Sex-specific interaction between APOE genotype and carbohydrate intake affects plasma HDL-C levels: the Strong Heart Family Study

Table 4 P values for tests of main effects and interaction of sex, APOE and carbohydrate, with table representing results of maximum model (basic adjustment and adjustment for measures of diabetes, body fat, glucose and fasting insulin)

	Gender × Carb. × ApoE interaction^a	Carb. × ApoE interaction^b	Carb. main effects^c	ApoE main effects^c
Log(HDL)
Sex-combined	0.0002
Males		0.14	0.029	0.17
Females		0.0003	0.11	0.0006
Log(ApoA1)
Sex-combined	0.060
Males		0.084	0.14	<0.0001
Females		0.063	0.56	0.0023
Log(trigs)
Sex-combined	0.58
Males		0.47	0.018	0.54
Females		0.92	0.53	0.60

Adjustments made for basic model, then incremental additions with measures of diabetes, body fat, and fasting insulin and glucose levels. Interaction models adjusted for all lower order terms. Basic model adjusted for age, SHS center, BMI; Maximum model adjustment for 2 diabetes variables (s3adadm and s3adaifg), body fat (s3fat), glucose (s3g0) and fasting insulin (s3insu). Models with interactions are adjusted for all lower order terms
^aPerformed on sex-combined sample
^bPerformed on sex-stratified samples
^cPerformed on sex-stratified samples only if P value for carb × APOE interaction was not significant in the previous model

ISSN: 1865-3499