Fig. 1

Schematic representation of the sagittal view of a rodent brain highlighting the two neurogenic zones of the adult mammalian brain: the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the dentate gyrus (DG) in the hippocampus. Neurons generated in the SVZ migrate through the rostral migratory stream (RMS) and are incorporated into the olfactory bulb. The hippocampal region contained in the black square is enlarged showing (1) neural progenitor cells in the SGZ of the DG proliferating, (2) migrating into the granule cell layer and (3) maturing into new granule neurons. These integrate into the hippocampal circuitry by receiving inputs from the entorhinal cortex and extend projections into the CA3