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Table 2 Odds ratios (OR) for obesity risk and linear regression coefficients for the association between the rs9939609 of FTO gene and Pro12Ala SNPs of the PPARG2 gene and BMI in elderly participants of the SUN Project

From: Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

  

OR (95 % CI) for obesity

p value

p for interactiona

B (95 % CI)b

p value

p for interactionc

PPARG2 (rs1801282)

 Pro12Pro

 

1 (ref)

  

0 (ref)

  

 Ala12

 

1.66 (1.01–2.74)

0.045

 

0.40 (−0.13–0.90)

0.139

 

FTO (rs9939609)

 TT

 

1 (ref)

  

0 (ref)

  

 TA/AA

 

1.03 (0.66–1.60)

0.892

 

0.33 (−0.08–0.74)

0.112

 

Genotype

 FTO e

PPARG2 e

      

 −

1 (ref)

  

0 (ref)

  

 −

+

1.92 (0.86–4.27)

0.111

 

0.46 (−0.36–1.30)

0.287

 

 +

1.10 (0.66–1.84)

0.704

 

0.34 (−0.11–0.79)

0.135

 

 +

+

1.71 (0.84–3.48)

0.138

 

0.79 (0.08–1.50)

0.030

 

High CHO intake (>246 g/day)

   

model 1/model 2

   

PPARG2 (rs1801282)

   

0.046/0.030

  

0.260

 Pro12Pro

 

1 (ref)

  

0 (ref)

  

 Ala12

 

2.67 (1.30–5.46)

0.007d

 

0.49 (−0.21–1.20)

0.169

 

FTO (rs9939609)

   

0.609/0.449

  

0.739

 TT

 

1 (ref)

  

0 (ref)

  

 TA/AA

 

1.15 (0.57–2.31)

0.697

 

0.46 (−0.11–1.03)

0.111

 

Genotype

 FTO e

PPARG2 e

  

0.814/0.844

  

0.973

 −

1 (ref)

  

0 (ref)

  

 −

+

1.92 (0.79–6.76)

0.312

 

0.28 (−0.03–1.43)

0.639

 

 +

1.04 (0.60–2.41)

0.924

 

0.41 (−0.22–1.03)

0.204

 

 +

+

3.26 (1.19–8.89)

0.021

 

1.07 (0.10–2.03)

0.031

 

Low physical activity practice (< 18.6 METs-h/week)

   

model 3/model 4

   

PPARG2 (rs1801282)

   

0.266/0.243

  

0.741

 Pro12Pro

 

1 (ref)

  

0 (ref)

  

 Ala12

 

2.14 (1.13–4.05)

0.020

 

0.93 (0.16–1.69)

0.017d

 

 FTO (rs9939609)

   

0.366/0.152

  

0.417

 TT

 

1 (ref)

  

0 (ref)

  

 TA/AA

 

1.14 (0.64–2.06)

0.652

 

0.56 (−0.05–1.16)

0.070

 

Genotype

 FTO e

PPARG2 e

  

0.346/0.230

  

0.360

 −

1 (ref)

  

0 (ref)

  

 −

+

2.31 (0.79–6.76)

0.125

 

0.63 (−0.65–1.90)

0.334

 

 +

1.21 (0.60–2.41)

0.594

 

0.48 (−0.18–1.14)

0.156

 

 +

+

2.51 (1.01–6.23)

0.047

 

1.67 (0.63–2.71)

0.002d

 
  1. Adjusted for gender, age, physical activity and total energy intake
  2. model 1: interaction term = genotype*CHO (dichotomized at the median); model 2: interaction term = genotype*CHO (continuous); model 3: interaction term = genotype*PA (dichotomized at the median); model 4: interaction term = genotype*PA (continuous)
  3. a p value for likelihood ratio test for obesity risk
  4. bAdjusted differences in average BMI (kg/m2) between genotypes
  5. c p value for interaction for BMI (as continuous variable)
  6. d p value <0.05 after correcting for Benjamini–Hochberg multiple comparisons
  7. e(−) Non-carriers of the minor risk alleles (+). Subjects carrying the minor risk alleles, either Pro12Ala of PPARG2 gene or rs9939609 of FTO gene