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Table 2 Associations of SNPs in PTGS1 and ALOX15 and risk of colon cancer stratified by fat and fatty acid intake

From: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer

Gene

SNP

Fat/fatty acid

Genotype

Colon fat/fatty acid intake

Low

Intermediate

High

ORa (95 % CI)

ORa (95 % CI)

ORa (95 % CI)

PTGS1

rs10306110

EPA

AA

1.00

1.05 (0.87, 1.27)

0.99 (0.82, 1.19)

(−1,053 A > G)

AG/GG

1.56 (1.09, 2.22)

1.10 (0.77, 1.57)

0.77 (0.54, 1.10)

 

p-interactiona

 

0.006

 

Adjusted p b

 

0.10

 

DHA

AA

1.00

1.16 (0.96, 1.40)

1.07 (0.88, 1.31)

AG/GG

1.62 (1.14, 2.30)

1.17 (0.82, 1.66)

0.82 (0.57, 1.18)

p-interactiona

 

0.003

 

Adjusted p b

 

0.06

 

ALOX15

rs11568131

EPA

GG

1.00

0.98 (0.80, 1.20)

0.80 (0.65, 0.98)

 

(10,339 C > T)

GA/AA

0.80 (0.60, 1.05)

0.86 (0.66, 1.14)

1.00 (0.76, 1.32)

 

p-interactiona

 

0.02

 

Adjusted p b

 

0.36

 
  1. Only SNPs with statistically significant interactions are shown
  2. Bold values are statistically significant
  3. aAdjusted for age, study center, ethnicity, sex, family history of disease, recent NSAID use (where appropriate), BMI, physical activity, dietary cholesterol, and caloric intake
  4. bBonferroni adjusted