Gene | SNP | Fatty acid | Genotype | No recent aspirin/NSAID use | Recent aspirin/NSAID use | ||
---|---|---|---|---|---|---|---|
Low | High | Low | High | ||||
ORa (95Â % CI) | ORa (95Â % CI) | ORa (95Â % CI) | ORa (95Â % CI) | ||||
ALOX12 | rs11571339 (7,135 AÂ >Â G) | n-3 | AA | 1 | 1.26 (1.01, 1.59) | 1 | 0.93 (0.67, 1.29) |
 | AG/GG | 1.16 (0.84, 1.59) | 0.81 (0.56, 1.18) | 0.72 (0.45, 1.16) | 1.02 (0.60, 1.73) | ||
 | p-interaction (2-way)a |  | 0.02 | 0.23 |  | ||
 | p-interaction (3-way)a |  | 0.02 |  |  | ||
rs312462 (14,215 CÂ >Â T) | SFA | GG | 1 | 0.97 (0.76, 1.22) | 1 | 1.41 (1.02, 1.96) | |
 | GA | 0.72 (0.52, 0.99) | 1.18 (0.84, 1.66) | 1.32 (0.86, 2.04) | 1.14 (0.71, 1.82) | ||
L634L | Â | AA | 0.61 (0.18, 2.15) | 0.63 (0.15, 2.56) | 1.52 (0.35, 6.57) | 1.02 (0.16, 6.31) | |
 | p-interaction (2-way)a |  | 0.03 | 0.09 |  | ||
 | p-interaction (3-way)a |  | 0.01 |  |  | ||
ALOX15 | rs11568075 (305 CÂ >Â T) | 20:05 | GG | 1 | 0.80 (0.67, 0.97) | 1 | 1 (0.77, 1.31) |
 | GA/AA | 0.71 (0.50, 1.01) | 1.03 (0.71, 1.51) | 1.89 (1.19, 2.99) | 1.23 (0.75, 2.02) | ||
 | p-interaction (2-way)a |  | 0.02 | 0.21 |  | ||
 | p-interaction (3-way)a |  | 0.02 |  |  | ||
FLAP | rs3803278 (8,663 TÂ >Â C) | n-3 | AA | 1 | 1.2 (0.93, 1.55) | 1 | 0.9 (0.63, 1.29) |
 | AG | 1.06 (0.82, 1.37) | 1.2 (0.89, 1.61) | 0.88 (0.63, 1.23) | 0.94 (0.62, 1.41) | ||
 | GG | 1.04 (0.58, 1.87) | 0.92 (0.53, 1.61) | 0.38 (0.15, 0.94) | 1.22 (0.55, 2.73) | ||
 | p-interaction (2-way)a |  | 0.46 | 0.08 |  | ||
 | p-interaction (3-way)a |  | 0.048 |  |  | ||
rs9315053 (29,380 TÂ >Â G) | 18:02b | AA | 1 | 1.42 (1.06, 1.90) | 1 | 0.73 (0.49, 1.08) | |
 | AC | 1.21 (0.95, 1.55) | 1.21 (0.90, 1.61) | 0.83 (0.59, 1.15) | 0.95 (0.64, 1.41) | ||
 | CC | 1.3 (0.89, 1.91) | 0.81 (0.52, 1.26) | 0.7 (0.40, 1.23) | 0.6 (0.28, 1.28) | ||
 | p-interaction (2-way)a |  | 0.003 | 0.17 |  | ||
 | p-interaction (3-way)a |  | 0.01 |  |  | ||
FLAP | rs4293222 (2,034 CÂ >Â G) | SFA | CC | 1 | 1.01 (0.76, 1.36) | 1 | 1.52 (1.02, 2.26) |
 | CG | 1.04 (0.80, 1.36) | 1.08 (0.80, 1.45) | 1.12 (0.78, 1.62) | 1.3 (0.86, 1.97) | ||
 | GG | 0.94 (0.63, 1.41) | 1.31 (0.86, 1.99) | 1.59 (0.95, 2.67) | 1.39 (0.78, 2.47) | ||
 | p-interaction (2-way)a |  | 0.36 | 0.11 |  | ||
 | p-interaction (3-way)a |  | 0.04 |  |  | ||
rs17245197 (13,834 CÂ >Â G) | PUFA | GG | 1 | 1.05 (0.85, 1.30) | 1 | 0.98 (0.72, 1.34) | |
 | GC/CC | 0.89 (0.51, 1.56) | 1.49 (0.78, 2.83) | 2.19 (1.11, 4.34) | 0.74 (0.30, 1.83) | ||
 | p-interaction (2-way)a |  | 0.28 | 0.06 |  | ||
 | p-interaction (3-way)a |  | 0.03 |  |  | ||
Indel | 23A/23A | Â | 1 | 1.01 (0.79, 1.28) | 1 | 1.09 (0.78, 1.53) | |
23A/19A or 19A/19A | Â | 1.06 (0.81, 1.38) | 1.35 (0.98, 1.85) | 1.23 (0.85, 1.77) | 0.83 (0.52, 1.31) | ||
 | p-interaction (2-way)a |  | 0.25 | 0.09 |  | ||
 | p-interaction (3-way)a |  | 0.028 |  |  | ||
ALOX5 | 6pb VNTR | 22:05 | ≥5/≥5 | 1 | 0.87 (0.71, 1.08) | 1 | 1.11 (0.83, 1.48) |
 | <5/≤5 | 0.77 (0.59, 1.00) | 0.98 (0.75, 1.29) | 1.28 (0.88, 1.84) | 0.99 (0.69, 1.44) | ||
 | p-interaction (2-way)a |  | 0.042 | 0.18 |  | ||
 | p-interaction (3-way)a |  | 0.029 |  |  | ||
22:06 | ≥5/≥5 | 1 | 0.78 (0.63, 0.97) | 1 | 0.92 (0.68, 1.23) | ||
 | <5/≤5 | 0.74 (0.57, 0.97) | 0.92 (0.70, 1.21) | 1.18 (0.82, 1.69) | 0.88 (0.60, 1.28) | ||
 | p-interaction (2-way)a |  | 0.015 | 0.43 |  | ||
 | p-interaction (3-way)a |  | 0.043 |  |  |