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Table 5 Associations of SNPs in PTGS1 and their interactions with NSAID use with risk of rectal cancer stratified by fat and FA intake

From: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer

Gene

SNP

Fatty acid

Genotype

No recent aspirin/NSAID use

Recent aspirin/NSAID use

Low

High

Low

High

ORa (95 % CI)

ORa (95 % CI)

ORa (95 % CI)

ORa (95 % CI)

PTGS1

rs1330344 (−1,676 T > C9

22:06

AA

1

0.97 (0.68, 1.39)

1

0.63 (0.41, 0.98)

 

AG/GG

1.08 (0.74, 1.58)

0.81 (0.54, 1.21)

0.57 (0.35, 0.91)

1.21 (0.76, 1.91)

 

p-interaction (2-way)a

 

0.34

0.0003

 
 

p-interaction (3-way)a

 

0.001

  

rs10306122 (2,125 T > C)

PUFA

AA

1

0.99 (0.69, 1.43)

1

0.84 (0.55, 1.30)

 

AG/GG

2.17 (1.13, 4.14)

0.61 (0.35, 1.06)

1.11 (0.51, 2.40)

1.07 (0.58, 1.99)

 

p-interaction (2-way)a

 

0.002

0.77

 
 

p-interaction (3-way)a

 

0.02

  

18:02

AA

1

1.01 (0.70, 1.46)

1

0.86 (0.56, 1.33)

 

AG/GG

2.23 (1.17, 4.24)

0.61 (0.35, 1.05)

1.2 (0.56, 2.57)

1.05 (0.56, 1.97)

 

p-interaction (2-way)a

 

0.0009

0.97

 
 

p-interaction (3-way)a

 

0.03

  
  1. Only SNPs with statistically significant interactions are shown
  2. Bold values are statistically significant
  3. aAdjusted for age, study center, ethnicity, sex, family history of disease, recent NSAID use (where appropriate), BMI, physical activity, dietary cholesterol, and caloric intake