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Fig. 1 | Genes & Nutrition

Fig. 1

From: Current status on genome–metabolome-wide associations: an opportunity in nutrition research

Fig. 1

a Manhattan plot resulting from a GWAS that uses as input phenotype the intensity of a 1H-NMR chemical shift centered at 2.032 ppm. This chemical shift peak has been assigned to an N-acetylated compound, possibly N-acetylated proteins. The plot shows a strong association with a large number of SNPs on chromosome 2. A close-up (b) of the genomic regions shows that the center of the association peak lies clearly on the ALMS1 gene and not on the neighboring NAT8 gene. The QQ-plot (c) shows that a large number of SNPs are strongly associated with this compound. The fact that all the significant associations come from the same locus (panel a and b) underlines the existence of strong LD in this genome region

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