From: The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
 | All PNPLA3 genotype | Normal weight (BMI ≤ 25) PNPLA3 genotype | Overweight (BMI > 25) PNPLA3 genotype | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | CC | CG | GG | P trenda | CC | CG | GG | P trend | CC | CG | GG | P trend | |
N | 4,827 | 3,028 | 1,605 | 194 | Â | 1,465 | 780 | 101 | Â | 1,561 | 824 | 93 | Â |
Age (years) | 4,827 | 58.3 | 58.1 | 58.3 | 0.42 | 57.2 | 57.3 | 57.3 | 0.50 | 58.0 | 58.2 | 58.1 | 0.46 |
BMI (kg/m2) | 4,824 | 25.7 | 25.7 | 25.8 | 0.57 | 23.0 | 23.0 | 23.0 | 0.12 | 28.4 | 28.5 | 28.0 | 0.87 |
Triglycerides (mmol/L) | 4,827 | 1.40 | 1.35 | 1.33 | 0.34 | 1.20 | 1.20 | 1.26 | 0.09 | 1.57 | 1.50 | 1.39 | 0.01 |
VLDLl (mmol/L) | 4,131 | 9.55 | 9.22 | 9.20 | 0.07 | 8.74 | 8.70 | 9.22 | 0.56 | 10.3 | 9.80 | 9.24 | 0.002 |
LDL (mmol/L) | 4,713 | 4.18 | 4.13 | 4.18 | 0.20 | 4.10 | 4.04 | 4.21 | 0.61 | 4.30 | 4.23 | 4.17 | 0.04 |
HDL (mmol/L) | 4,770 | 1.36 | 1.36 | 1.38 | 0.80 | 1.45 | 1.45 | 1.44 | 0.79 | 1.28 | 1.27 | 1.32 | 0.70 |
S-ALT (U/L)b | 7,198 | 0.35 | 0.36 | 0.39 | 0.005 | 0.32 | 0.32 | 0.34 | 0.65 | 0.37 | 0.39 | 0.43 | 0.001 |
Fasting glucose (mmol/L) | 4,812 | 5.70 | 5.65 | 5.65 | 0.24 | 5.50 | 5.50 | 5.50 | 0.65 | 5.85 | 5.80 | 5.82 | 0.11 |
Fasting insulin (pmol/L) | 4,655 | 7.91 | 8.00 | 7.25 | 0.30 | 5.80 | 6.00 | 6.26 | 0.80 | 9.80 | 9.80 | 8.13 | 0.40 |
HOMA-IR | 4,430 | 1.61 | 1.70 | 1.60 | 0.70 | 1.23 | 1.28 | 1.33 | 0.92 | 2.00 | 2.03 | 1.84 | 0.78 |
HbA1c (%) | 4,806 | 4.82 | 4.79 | 4.85 | 0.23 | 4.80 | 4.80 | 4.80 | 0.90 | 4.86 | 4.81 | 4.94 | 0.23 |
Total energy intake (kcal/day) | 4,827 | 2,349 | 2,350 | 2,347 | 0.82 | 2,453 | 2,419 | 2,426 | 0.22 | 2,337 | 2,356 | 2,298 | 0.84 |
Carbohydrate (E%) | 4,827 | 47.0 | 47.0 | 47.0 | 0.54 | 47.0 | 47.2 | 46.5 | 0.92 | 46.6 | 47.2 | 46.5 | 0.12 |
Sucrose (E%) | 4,827 | 8.40 | 8.40 | 8.50 | 0.82 | 8.42 | 8.31 | 7.74 | 0.08 | 8.30 | 8.10 | 8.40 | 0.35 |
Fiber (g/1,000Â kcal) | 4,827 | 9.16 | 9.21 | 9.20 | 0.22 | 9.43 | 9.73 | 9.60 | 0.05 | 9.43 | 9.63 | 9.40 | 0.20 |
Total ω-3 PUFA (E%) | 4,827 | 0.97 | 0.97 | 0.98 | 0.95 | 0.97 | 0.96 | 1.00 | 0.93 | 1.00 | 1.00 | 1.04 | 0.63 |
Total ω-6 PUFA (E%) | 4,827 | 4.83 | 4.84 | 4.93 | 0.09 | 4.90 | 4.93 | 5.10 | 0.13 | 4.94 | 4.90 | 4.90 | 0.17 |
Total ω-6:ω-3 PUFA ratio | 4,827 | 5.22 | 5.25 | 5.26 | 0.12 | 5.24 | 5.40 | 5.35 | 0.05 | 5.30 | 5.31 | 5.01 | 0.60 |