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Table 1 Characteristics of the Malmö Diet and Cancer study cohort by the PNPLA3 rs738409 genotype

From: The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels

 

All

PNPLA3 genotype

Normal weight (BMI ≤ 25)

PNPLA3 genotype

Overweight (BMI > 25)

PNPLA3 genotype

N

CC

CG

GG

P trenda

CC

CG

GG

P trend

CC

CG

GG

P trend

N

4,827

3,028

1,605

194

 

1,465

780

101

 

1,561

824

93

 

Age (years)

4,827

58.3

58.1

58.3

0.42

57.2

57.3

57.3

0.50

58.0

58.2

58.1

0.46

BMI (kg/m2)

4,824

25.7

25.7

25.8

0.57

23.0

23.0

23.0

0.12

28.4

28.5

28.0

0.87

Triglycerides (mmol/L)

4,827

1.40

1.35

1.33

0.34

1.20

1.20

1.26

0.09

1.57

1.50

1.39

0.01

VLDLl (mmol/L)

4,131

9.55

9.22

9.20

0.07

8.74

8.70

9.22

0.56

10.3

9.80

9.24

0.002

LDL (mmol/L)

4,713

4.18

4.13

4.18

0.20

4.10

4.04

4.21

0.61

4.30

4.23

4.17

0.04

HDL (mmol/L)

4,770

1.36

1.36

1.38

0.80

1.45

1.45

1.44

0.79

1.28

1.27

1.32

0.70

S-ALT (U/L)b

7,198

0.35

0.36

0.39

0.005

0.32

0.32

0.34

0.65

0.37

0.39

0.43

0.001

Fasting glucose (mmol/L)

4,812

5.70

5.65

5.65

0.24

5.50

5.50

5.50

0.65

5.85

5.80

5.82

0.11

Fasting insulin (pmol/L)

4,655

7.91

8.00

7.25

0.30

5.80

6.00

6.26

0.80

9.80

9.80

8.13

0.40

HOMA-IR

4,430

1.61

1.70

1.60

0.70

1.23

1.28

1.33

0.92

2.00

2.03

1.84

0.78

HbA1c (%)

4,806

4.82

4.79

4.85

0.23

4.80

4.80

4.80

0.90

4.86

4.81

4.94

0.23

Total energy intake (kcal/day)

4,827

2,349

2,350

2,347

0.82

2,453

2,419

2,426

0.22

2,337

2,356

2,298

0.84

Carbohydrate (E%)

4,827

47.0

47.0

47.0

0.54

47.0

47.2

46.5

0.92

46.6

47.2

46.5

0.12

Sucrose (E%)

4,827

8.40

8.40

8.50

0.82

8.42

8.31

7.74

0.08

8.30

8.10

8.40

0.35

Fiber (g/1,000 kcal)

4,827

9.16

9.21

9.20

0.22

9.43

9.73

9.60

0.05

9.43

9.63

9.40

0.20

Total ω-3 PUFA (E%)

4,827

0.97

0.97

0.98

0.95

0.97

0.96

1.00

0.93

1.00

1.00

1.04

0.63

Total ω-6 PUFA (E%)

4,827

4.83

4.84

4.93

0.09

4.90

4.93

5.10

0.13

4.94

4.90

4.90

0.17

Total ω-6:ω-3 PUFA ratio

4,827

5.22

5.25

5.26

0.12

5.24

5.40

5.35

0.05

5.30

5.31

5.01

0.60

  1. General linear model adjusted for age and sex when applicable
  2. Normal-weight and overweight individuals were set on BMI ≤ 25 and BMI > 25 kg/m2
  3. a P values are calculated from ln transformed variables when appropriate
  4. bALT levels were analyzed for 7,198 individuals of MDC cohort in another project, the Malmö Preventive Project (35)