From: The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
Triglycerides | Range | All PNPLA3 genotype | Normal weight (BMI ≤ 25) PNPLA3 genotype | Overweight (BMI > 25) PNPLA3 genotype | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Min–max | CC | CG | GG | P trenda | CC | CG | GG | P trenda | CC | CG | GG | P trenda | |
Carbohydrates E% | |||||||||||||
N | Â | 3,028 | 1,605 | 194 | Â | 1,465 | 780 | 101 | Â | 1,561 | 824 | 93 | Â |
1st tertile | 16–44 | 1.64 1.20, 2.11 | 1.54 1.10, 2.01 | 1.45 0.95, 1.95 | 0.02 | 1.29 1.13, 1.46 | 1.21 1.04, 1.38 | 1.27 1.02, 1.53 | 0.67 | 1.73 1.16, 2.31 | 1.65 1.07, 2.24 | 1.40 0.74, 2.05 | 0.04 |
2nd tertile | 44–49 | 1.59 1.12, 2.10 | 1.61 1.14, 2.10 | 1.52 1.02, 2.02 | 0.56 | 1.21 1.05, 1.38 | 1.27 1.10, 1.44 | 1.31 1.05, 1.57 | 0.04 | 1.74 1.16, 2.31 | 1.70 1.12, 2.29 | 1.50 0.86, 2.13 | 0.24 |
3rd tertile | 49–81 | 1.61 1.14, 2.10 | 1.60 1.13, 2.10 | 1.69 1.20, 2.20 | 0.92 | 1.28 1.12, 1.44 | 1.33 1.16, 1.50 | 1.44 1.17, 1.70 | 0.22 | 1.74 1.16, 2.31 | 1.67 1.09, 2.25 | 1.72 1.08, 2.36 | 0.24 |
P trendb | Â | 0.63 | 0.08 | 0.40 | Â | 0.89 | 0.02 | 0.40 | Â | 0.85 | 0.55 | 0.13 | Â |
(P interactionb) | Â | Â | Â | Â | (0.07) | Â | Â | Â | (0.12) | Â | Â | Â | (0.51) |
Sucrose E% | |||||||||||||
N | Â | 3,028 | 1,605 | 194 | Â | 1,465 | 780 | 101 | Â | 1,561 | 824 | 93 | Â |
1st tertile | 0.60–6.70 | 1.61 1.15, 2.10 | 1.56 1.10, 2.04 | 1.42 0.92, 1.92 | 0.15 | 1.27 1.11, 1.43 | 1.22 1.05, 1.39 | 1.26 1.02, 1.50 | 0.54 | 1.72 1.14, 2.29 | 1.68 1.10, 2.27 | 1.36 0.71, 2.01 | 0.06 |
2nd tertile | 6.70–9.31 | 1.61 1.14, 2.10 | 1.57 1.10, 2.05 | 1.55 1.05, 2.05 | 0.31 | 1.26 1.10, 1.42 | 1.24 1.07, 1.41 | 1.24 1.00, 1.49 | 0.42 | 1.73 1.15, 2.31 | 1.67 1.08, 2.25 | 1.64 1.01, 2.28 | 0.34 |
3rd tertile | 9.31–38.0 | 1.62 1.15, 2.10 | 1.62 1.15, 2.10 | 1.73 1.22, 2.24 | 0.34 | 1.27 1.11, 1.43 | 1.35 1.18, 1.52 | 1.61 1.32, 1.89 | 0.001 | 1.76 1.18, 2.33 | 1.68 1.09, 2.26 | 1.61 0.96, 2.26 | 0.12 |
P trendb | Â | 0.31 | 0.05 | 0.06 | Â | 0.42 | 0.008 | 0.69 | Â | 0.29 | 0.57 | 0.39 | Â |
(P interactionb) | Â | Â | Â | Â | (0.07) | Â | Â | Â | (0.03) | Â | Â | Â | (0.17) |
ω-6:ω-3 PUFA ratio | |||||||||||||
N | Â | 3,028 | 1,605 | 194 | Â | 1,465 | 780 | 101 | Â | 1,561 | 824 | 93 | Â |
1st tertile | 0.60–4.50 | 1.60 1.12, 2.10 | 1.52 1.04, 2.00 | 1.47 1.00, 2.00 | 0.10 | 1.23 1.07, 1.39 | 1.24 1.06, 1.40 | 1.33 1.07, 1.59 | 0.19 | 1.73 1.15, 2.31 | 1.60 1.01, 2.18 | 1.42 0.78, 2.05 | 0.001 |
2nd tertile | 4.50–6.00 | 1.59 1.12, 2.10 | 1.64 1.20, 2.11 | 1.48 1.00, 2.00 | 0.43 | 1.22 1.06, 1.38 | 1.33 1.16, 1.50 | 1.14 0.83, 1.45 | 0.10 | 1.74 1.16, 2.32 | 1.73 1.15, 2.32 | 1.54 0.90, 2.18 | 0.61 |
3rd tertile | 6.00–31.0 | 1.63 1.20, 2.10 | 1.56 1.10, 2.03 | 1.66 1.20, 2.20 | 0.37 | 1.31 1.15, 1.47 | 1.23 1.06, 1.39 | 1.42 1.19, 1.65 | 1.00 | 1.72 1.15, 2.30 | 1.70 1.10, 2.27 | 1.73 1.07, 2.38 | 0.64 |
P trendb | Â | 0.04 | 0.54 | 0.16 | Â | 0.01 | 0.55 | 0.66 | Â | 0.80 | 0.13 | 0.48 | Â |
(P interactionb) | Â | Â | Â | Â | (0.82) | Â | Â | Â | (0.22) | Â | Â | Â | (0.08) |