Fig. 3
Effect of the MTRR 66A>G and MTRR 524C>T polymorphisms on tHcy according to riboflavin or riboflavin combined with cobalamin status. Effect of the variant MTRR 66G variant allele compared to the 66AA genotype on tHcy according to EGRAC status (a) or EGRAC and plasma cobalamin status (above or in the lowest quartile, ≤273 pmol/L) (b). Effect of the variant MTRR 524T allele compared to the 524CC genotype on tHcy according to EGRAC status (c) or EGRAC and plasma cobalamin status (above or in the lowest tertile, ≤273 pmol/L) (d). LntHcy was the dependent variable in the multiple linear regression analyses represented in all panels. Models were adjusted for plasma cobalamin, folate and creatinine, EASTAC, smoking habit (smoker versus non-smoker), alcohol intake (g/week), age, sex, MTHFR 677C>T polymorphism, BMI, socioeconomic level and study centre. The interaction term (EGRAC × genotype) was included in the models and, when significant, indicated that riboflavin status altered the association between the genotype and tHcy. All of the models were significant (p < 0.001) with R 2 ranging from 0.309 to 0.887 for the MTRR 66A>G polymorphism and from 0.309 and 0.591 for the MTRR 524C>T polymorphism. *p < 0.05 variant MTRR 524T allele compared to 524CC