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Fig. 4 | Genes & Nutrition

Fig. 4

From: γ-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells

Fig. 4

Number of genes and the top molecular and cellular functions associated with the GGH-specific gene expression. We identified genes differentially expressed in the opposite direction between GGH overexpression and inhibition to investigate genes associated with the GGH-specific altered expression in the GGH-modulated HCT116 and MDA-MB-435 cell lines. Twenty-eight (a) and 80 genes (b) that were downregulated in response to GGH overexpression and upregulated in response to GGH inhibition were identified in HCT116 and MDA-MB-435 cell lines, respectively. We identified that 11 (a) and 133 genes (b) were upregulated in response to GGH overexpression and downregulated associated with GGH inhibition in HCT116 and MDA-MB-435 cell lines, respectively

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