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Table 1 Number of genes and the top molecular and cellular functions associated with genes with altered expression and promoter DNA methylation in the GGH-modulated HCT116 and MDA-MB-435 cells

From: γ-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells

Cell line

GGH modulation

No. of genes

Top function

  

Hypermethylated and downregulated

Downregulated

 

HCT116

Overexpression

4

91

N/A

Inhibition

3

139

Cell-to-cell signaling and interaction, cellular development, cellular growth and proliferation, gene expression, lipid metabolism

MDA-MB-435

Overexpression

26

628

Cell signaling, cellular assembly and organization, cellular movement, drug metabolism, lipid metabolism

Inhibition

17

402

Cell morphology, cellular development, gene expression, cellular assembly and organization, cell-to-cell signaling and interaction

  

Hypomethylated and upregulated

Upregulated

 

HCT116

Overexpression

1

61

Cellular growth and proliferation

Inhibition

13

182

Lipid metabolism, small molecule biochemistry, carbohydrate metabolism, cellular movement, drug metabolism

MDA-MB-435

Overexpression

75

755

Cellular assembly and organization, cell-to-cell signaling and interaction, cellular growth and proliferation, cellular development, cell death

Inhibition

30

457

Cell morphology, cell cycle, cellular growth and proliferation, cellular development, cellular movement

  1. N/A not available