Cell line | GGH modulation | No. of genes | Top function | |
---|---|---|---|---|
Hypermethylated and downregulated | Downregulated | |||
HCT116 | Overexpression | 4 | 91 | N/A |
Inhibition | 3 | 139 | Cell-to-cell signaling and interaction, cellular development, cellular growth and proliferation, gene expression, lipid metabolism | |
MDA-MB-435 | Overexpression | 26 | 628 | Cell signaling, cellular assembly and organization, cellular movement, drug metabolism, lipid metabolism |
Inhibition | 17 | 402 | Cell morphology, cellular development, gene expression, cellular assembly and organization, cell-to-cell signaling and interaction | |
Hypomethylated and upregulated | Upregulated | |||
HCT116 | Overexpression | 1 | 61 | Cellular growth and proliferation |
Inhibition | 13 | 182 | Lipid metabolism, small molecule biochemistry, carbohydrate metabolism, cellular movement, drug metabolism | |
MDA-MB-435 | Overexpression | 75 | 755 | Cellular assembly and organization, cell-to-cell signaling and interaction, cellular growth and proliferation, cellular development, cell death |
Inhibition | 30 | 457 | Cell morphology, cell cycle, cellular growth and proliferation, cellular development, cellular movement |