Fig. 1

Primary component analysis (PCA) score plot of blood and tissue biomarkers significantly altered by folic acid, B vitamins and fat intake in ApoE null mice. Mice were fed a control (C) or high-fat (HF) diet depleted of folic acid (F–) or folic acid and vitamins B₆ and B₁₂ (F–B–) for 16 weeks. Symbols represent individual replicate animals within every treatment group