Genes & Nutrition

Table 4 Associations (correlation analyses) between aorta lipid and aorta protein expression

From: Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice

Biomarker	Spot	Protein	Correlation	P value
Adventitia total cholesterol	829	Annexin A1	−0.500	4.69E−05
Adventitia total cholesterol	582	Protein-glutamine gamma-glutamyltransferase 2	0.413	0.00102
Adventitia total cholesterol	912	Isocitrate dehydrogenase	0.418	0.00088
Adventitia total cholesterol	524	Pyruvate kinase isozymes M1/M2	0.421	0.00079
Adventitia total cholesterol	468	78 kDa glucose-regulated protein	0.424	0.00072
Adventitia total cholesterol	473	Heat shock protein 1B	0.450	0.00030
Adventitia total cholesterol	604	Glutamate dehydrogenase 1	0.472	0.00013
Adventitia total cholesterol	557	Fibrinogen b polypeptide	0.484	9.09E−05
Adventitia total cholesterol	812	Electron transfer flavoprotein subunit α	0.495	5.85E−05
Adventitia total cholesterol	409	Serotransferrin	0.545	6.68E−06
Adventitia HDL	557	Fibrinogen b polypeptide	0.461	0.00020
Adventitia HDL	468	78 kDa glucose-regulated protein	0.556	4.02−06
Adventitia HDL	409	Serotransferrin	0.676	3.14E−09
Adventitia HDL	473	Heat shock protein 1B	0.687	1.30E−09
Adventitia NEFA	914	Vimentin	−0.451	0.00030
Adventitia NEFA	772	Aldose reductase	0.414	0.00101
Adventitia NEFA	812	Electron transfer flavoprotein subunit α	0.443	0.00038
Adventitia NEFA	468	78 kDa glucose-regulated protein	0.471	0.00014
Adventitia NEFA	524	Pyruvate kinase isozymes M1/M2	0.472	0.00014
Adventitia NEFA	604	Glutamate dehydrogenase 1	0.487	8.32E−05
Adventitia NEFA	912	Isocitrate dehydrogenase	0.497	5.45E−05
Adventitia NEFA	909	GTP-binding nuclear protein Ran	0.573	1.71E−06
Adventitia MUFA	557	Fibrinogen β polypeptide	−0.467	0.00024
Adventitia MUFA	410	Serotransferrin	−0.457	0.00035
Adventitia MUFA	503	Stress-induced-phosphoprotein 1	−0.429	0.00085
Adventitia SATFA	1,125	Transgelin	−0.512	4.72E−05

Analysis of associations between aorta tissue protein expression and vascular lipids was carried out for all mice in all treatment groups using Pearson’s correlation coefficients. Lipid biomarker, spot number, protein name and strength of association (positive and negative) are shown together with the corresponding P value. B ₁₂ vitamin B₁₂, HDL high-density lipoprotein, LDL low-density lipoprotein, MUFAs monounsaturated fatty acids, PUFAs polyunsaturated fatty acids, NEFA non-esterified fatty acids, SATFAs saturated fatty acids

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