Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

Table 3 Associations between dietary inflammatory index score (continuous) and colorectal cancer risk by polymorphisms in inflammatory genes in the Bellvitge Colorectal Cancer Study

Gene	Rs number	Trivial name	Cases	Controls	OR (95 % CI)^a	P for interaction^b
IL4 ^c	rs2243250	−588 C>T				0.004
CC			209	207	1.04 (0.95–1.13)
CT+TT			65	59	1.34 (1.14–1.57)
IL6 ^c	rs1800795	174 G>C				0.26
GG			131	143	1.12 (1.01–1.24)
GC+CC			222	163	1.04 (0.96–1.13)
IL8 ^c	rs4073	−251 T>A				0.85
TT			114	81	1.11 (0.98–1.25)
TA+AA			230	222	1.09 (1.01–1.19)
PPARG ^c	rs1801282	34 C>G				0.49
CC			305	238	1.09 (1.01–1.17)
CG+GG			46	65	1.03 (0.88–1.20)

IL interleukin, PPARG peroxisome proliferator-activated receptor-γ
^aIncrease in CRC risk for each unit of DII score. Adjusted for sex, age, total energy intake, body mass index, first-degree family history of colorectal cancer, physical activity, tobacco consumption, and medication use (aspirin and nonsteroidal anti-inflammatory drug)
^bDifferences in risk associated to dietary inflammatory index score by genotype
^cNot available data for some individuals produce OR estimates different from the complete dataset shown in Table 2 (OR 1.08, 95 % CI 1.01–1.15). Missing values for IL-4: 150 cases and 135 controls, for IL-6: 71 cases and 95 controls, for IL-8: 80 cases and 98 controls, and for PPARG: 72 cases and 98 controls

ISSN: 1865-3499