Skip to main content

Table 1 Ranked biological pathways based on Z score

From: Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D3-treated cancer cells

Pathway

Positive

Measured

Z score

p value

Cancer/general

Retinoblastoma (RB) in cancer

35

87

12.63

0.001

Cancer

DNA replication

22

42

11.91

0.001

General

Cell cycle

34

100

11.04

0.001

General

Gastric cancer network 1

15

26

10.44

0.001

Cancer

Histone modifications

25

64

10.44

0.001

General

G1-to-S cell cycle control

23

67

9.12

0.001

General

DNA damage response

15

64

5.4

0.001

General

Gastric cancer network 2

9

30

5.13

0.001

Cancer

ATM signalling pathway

10

38

4.87

0.001

General

Fluoropyrimidine activity

8

32

4.16

0.001

General

Integrated pancreatic cancer pathway

27

195

4.08

0.001

Cancer

Integrated cancer pathway

8

35

3.85

0.005

Cancer

Integrated breast cancer pathway

21

157

3.41

0.002

Cancer

Arylhydrocarbon receptor (AhR) signalling pathway

5

27

2.47

0.015

General

Signalling pathways in glioblastoma

10

82

2.02

0.048

Cancer

  1. Pathway statistics identified 15 significantly altered pathways in 1,25(OH)2D3-treated prostate cancer cells (Z score >1.96, p value <0.05 and minimum number of positive genes is five). Besides eight more general cell cycle-related pathways, pathway analysis also revealed seven cancer-specific pathways that are changed. Measured is number of gene products in the pathway that are measured in the data set, and positive is the number of differentially expressed genes in the pathway