Brain xanthophyll content and exploratory gene expression analysis: subspecies differences in rhesus macaque

Genes & Nutrition

Table 1 Relative expression of genes (fold change, Chinese vs. Indian) involved in xanthophyll uptake and metabolism in prefrontal cortex (PFC), cerebellum (CER), and striatum (STR) of Indian and Chinese-origin rhesus monkeys (n = 3 per group)

	Fold change-PFC	p value	Fold change-CER	p value	Fold change-STR	p value
BCO1	−1.15	0.77	2.75	0.99	1.84	0.37
BCO2	1.64	0.006	1.58	0.13	1.69	0.01
NPC1L1	1.54	0.34	−1.06	0.91	1.26	0.60
ABCG5	−1.37	0.99	1.17	0.68	1.06	0.91
ABCA1	1.05	0.84	−1.01	0.99	1.43	0.06
SCARB1	1.18	0.12	1.10	0.43	1.20	0.09
GSTP1	1.07	0.52	−1.09	0.59	1.15	0.38
STARD3	1.09	0.99	1.07	0.99	1.31	0.99
LIPC	−1.61	0.25	1.38	0.99	−1.37	0.46
ELOVL2	−1.02	0.87	1.06	0.71	1.08	0.67
ELOVL4	1.25	0.04	1.06	0.66	1.11	0.50
ELOVL5	1.14	0.49	−1.05	0.81	1.24	0.29
FADS1	1.17	0.15	1.20	0.20	1.55	0.01
FADS2	1.16	0.12	−1.04	0.75	1.32	0.05
RPE65	−1.28	0.44	−2.44	0.03	−1.37	0.26
ALDH3A2	−1.11	0.26	−1.05	0.61	1.02	0.89

Fold change calculated by dividing fragments per kilobase of transcript per million mapped reads (FPKM) Chinese origin by FPKM Indian origin. Genes in italics showed a significant difference in expression in at least one brain region. Genes in bold were selected for RT-PCR analysis

ISSN: 1865-3499