Fig. 5

Network of direct interactions between transcription factors HNF4alpha, SREBP1 and PPARA and genes involved in energy metabolism that were differentially expressed in lean subjects in response to intervention spread compared to control spread. Arrow pointing down indicates down-regulation of expression in response to intervention spread compared to control spread, arrow pointing up indicates up-regulation of expression in response to intervention spread compared to control spread. Lines between symbols indicate connections described in literature. This figure was made using MetaCore™ (v4.3) from GeneGo Inc. LIPA Lipase A, GPD1 glycerol-3-phosphate dehydrogenase 1, UCP2 mitochondrial uncoupling protein 2, DHCR7 7-dehydrocholesterol reductase; MVD diphosphomevalonate decarboxylase; ACACA acetyl-coA carboxylase 1; ACLY ATP citrate lyase; CISY citrate synthase; NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3; AD014(TOM7) translocase of outer mitochondrial membrane 7 homolog (yeast); UGTREL7 UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; THTPA thiamine-triphosphatase; SUOX Sulfite oxidase, mitochondrial precursor; PI4Kbeta: Phosphatidylinositol 4-kinase beta; 101F6: Cytochrome b561 domain-containing protein 2; TXNDC14: thioredoxin domain containing 14; PKM2 Pyruvate kinase 2/3; C14orf1: Probable ergosterol biosynthetic protein 28; PINK1 Serine/threonine-protein kinase PINK1, mitochondrial precursor; IFRD2 Interferon-related developmental regulator 2; HYAL3 Hyaluronidase-3 precursor; KARS Lysyl-tRNA synthetase; SLC35A2 UDP-galactose translocator