Table 2 Enriched functional groups (based on Gene Ontology) in total set of differentially expressed genes in lean versus overweight subjects (3,069 probesets), in genes expressed at high levels in lean than in overweight (1,325 probesets) and in genes expressed at higher levels in lean than overweight (1,744 probesets)
GO group | Functional group of genes | Number of genes measured | All genes | Higher in lean | Higher in overweight | |||
|---|---|---|---|---|---|---|---|---|
Percent changed | Z scorea | Percent changed | Z score | Percent changed | Z score | |||
CC | Mitochondrion | 522 | 38.5 | 14.4 | 34.3 | 25.7 | ||
BP | Generation of precursor metabolites and energy | 508 | 29.5 | 8.6 | 21.5 | 13.6 | ||
BP | Oxidative phosphorylation | 77 | 36.4 | 4.9 | 31.2 | 8.6 | ||
BP | Lipid metabolism | 503 | 27.6 | 7.3 | 17.9 | 10.2 | ||
BP | Carbohydrate metabolism | 392 | 25.5 | 5.3 | 12.5 | 4.7 | 13.0 | 2.6 |
BP | Glucose metabolism | 77 | 28.6 | 3.0 | 22.1 | 5.4 | ||
BP | Mitochondrial transport | 17 | 41.2 | 2.9 | 41.2 | 5.7 | ||
BP | Cell adhesion | 502 | 19.1 | 2.0 | 13.3 | 3.3 | ||
BP | Cell-matrix adhesion | 60 | 28.3 | 2.6 | 25.0 | 4.2 | ||
BP | Defense response | 723 | 24.2 | 6.3 | 21.5 | 11.8 | ||
BP | Inflammatory response | 183 | 26.2 | 3.8 | 24.6 | 7.2 | ||
BP | Response to stress | 829 | 20.6 | 3.8 | 17.0 | 8.0 | ||
BP | Intracellular signaling cascade | 930 | 19.1 | 2.8 | 13.8 | 5.0 | ||
BP | I-kappaB kinase/NF-kappaB cascade | 98 | 28.6 | 3.4 | 22.4 | 4.5 | ||
MF | Scavenger receptor activity | 28 | 32.1 | 2.4 | 32.1 | 4.2 | ||