Short-term fatty acid intervention elicits differential gene expression responses in adipose tissue from lean and overweight men

Table 3 Enriched functional groups (based on Gene Ontology) in set of differentially expressed genes (813 probesets) and in sub-set of down-regulated genes (509 probesets) in sub-group of lean subjects in response to treatment

GO group	Functional group of genes	Number of genes measured	All		Down-regulated
GO group	Functional group of genes	Number of genes measured	Percent changed	Z score	Percent changed	Z score
CC	Mitochondrion	522	6.5	3.1	5.7	4.1
BP	Generation of precursor metabolites and energy	508	6.9	3.5	5.5	3.7
BP	Lipid metabolism	503	6.2	2.7	5.8	4.0
BP	Carbohydrate metabolism	391	6.1	2.3	5.9	3.7
BP	Glucose metabolism	77	10.4	2.9	10.4	4.0
BP	Mitochondrial transport	17	23.5	4.2	23.5	5.1
BP	Regulation of cell cycle	367	6.27	2.36	4.9	2.4
BP	Complement activation\, classical pathway	22			13.6	3.0
BP	Oxygen and reactive oxygen species metabolism	65			7.7	2.4

Enrichment analysis was performed in GenMAPP, by comparing the two selected sets of genes (all genes differentially expressed in lean subjects in response to intervention and sub-set of down-regulated genes in lean subjects in response to treatment) to all genes on the microarray
GO Gene Ontology groups, CC cellular component, BP biological process
^aAll Z scores in table: P < 0.05 (PermuteP)

ISSN: 1865-3499