Fig. 5

Fisetin enhances long-term memory in older mice. Mice were fed fisetin (500 mg/kg of food) for 10 months beginning at 2 months of age. Learning and memory were tested using the morris water maze (MWM) [91]. Fisetin slightly but non-significantly enhanced learning in the mice as measured by the time taken to find a submerged platform over 7 days of training (left graph) and significantly enhanced memory as determined in the probe trial performed 24 h after the last training trial (right graph). Data represent the mean ± SD of 4–6 mice/treatment group. Data for the latency trials were analyzed by ANOVA and data from the probe trial were analyzed by t test. Asterisk indicates significantly different from control (P < 0.05)