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Fig. 6 | Genes & Nutrition

Fig. 6

From: CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

Fig. 6

a LPS plus pyrazole treatment activates JNK and p38 MAPK. b TNFα plus pyrazole treatment activates JNK and p38 MAPK as compared to TNFα alone treatment. The pJNK/JNK and the pp38 MAPK/p38MAPK ratios are shown below the blots. c Either the JNK inhibitor SP600125 (SP) or the p38 MAPK inhibitor SB203508 (SB) prevent TNFα plus pyrazole-induced elevation of ALT and AST or d liver pathology

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Genes & Nutrition

ISSN: 1865-3499

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