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Table 5 Postprandial apoB 48 and TRL triglycerides levels according to APOB-516C/T polymorphism

From: APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

 

C/C + C/T (n = 156)

T/T (n = 13)

P valuea

ApoB 48 T0 (mg/L)b

 Baseline

0.25 ± 0.20

0.16 ± 0.14

0.035

 3 months

0.27 ± 0.26

0.25 ± 0.23

0.052

 P valuec

0.518

0.173

 

ApoB 48 T2.5 (mg/L)d

 Baseline

0.51 ± 0.39

0.33 ± 0.26

0.011

 3 months

0.42 ± 0.42

0.36 ± 0.23

0.009

 P valuec

<0.001

0.382

 

ApoB 48 T5 (mg/L)e

 Baseline

0.61 ± 0.57

0.35 ± 0.22

0.060

 3 months

0.31 ± 0.30

0.33 ± 0.29

0.048

 P valuec

<0.001

0.422

 

TRL triglycerides T0 (mmol/L)b, f

 Baseline

1.11 ± 0.87

0.80 ± 0.67

0.040

 3 months

0.98 ± 0.78

0.81 ± 0.65

0.407

 P valuec

0.026

0.929

 

TRL triglycerides T2.5 (mmol/L)d

 Baseline

1.56 ± 1.04

1.09 ± 0.63

0.156

 3 months

1.39 ± 0.92

1.12 ± 0.80

0.857

 P valuec

0.081

0.534

 

TRL triglycerides T5 (mmol/L)e

 Baseline

1.84 ± 1.12

1.48 ± 0.81

0.312

 3 months

1.63 ± 0.96

1.33 ± 0.95

0.809

 P valuec

0.011

0.583

 
  1. The test meal provided 2,876 kJ, including 53% of energy as fat, 7% of energy as protein and 40% of energy as carbohydrates, and was eaten in 20 min
  2. Values are mean ± SD
  3. All parameters were adjusted for BMI
  4. Values in bold denote significant value for P
  5. aComparison between polymorphisms at baseline (tested with general linear models) and in their response to diet (tested with repeated measures general linear models)
  6. bMeasured at fasted state
  7. cP for comparison between baseline and 3 months (calculated by Student paired test for C/C + C/T and by Wilcoxon test for T/T)
  8. dMeasured 2.5 h after the test meal
  9. eMeasured 5 h after the test meal
  10. fAdjusted for apoB