Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein −493 G/T polymorphism and the usual diet in women

Table 2 Dietary intakes of subjects according to MTTP−493G/T polymorphism

69 women	G/G (2) n = 30	G/T (1) n = 30	T/T (3) n = 9	P value^a
Total energy (kJ)
Entry	7,237.6 ± 288.3	7,117.0 ± 310.9	7,929.4 ± 825.8	ns
Month 3	5,285.4 ± 226.6	5,279.8 ± 175.9	5,640.8 ± 281.2	ns
P value^b	<0.001	<0.001	0.011
Protein (g/d)
Entry	79.5 ± 2.6	73.9 ± 3.1	83.1 ± 7.4	ns
Month 3	61.1 ± 1.7	63.6 ± 2.7	69.4 ± 4.3	ns
P value^b	<0.001	0.011	0.021
Carbohydrate (g/d)
Entry	173.4 ± 8.3	181.4 ± 9.9	214.3 ± 19.8	ns
Month 3	141.0 ± 6.8	145.5 ± 6.3	155.1 ± 10.6	ns
P value^b	<0.001	<0.001	0.008
Total fat (g/d)
Entry	75.7 ± 4.1	73.5 ± 4.4	77.0 ± 13.6	ns
Month 3	48.4 ± 3.1	45.3 ± 2.1	49.0 ± 3.3	ns
P value^b	<0.001	<0.001	0.038
SFA (g/d)
Entry	27.2 ± 1.7	27.8 ± 2.2	28.6 ± 5.1	ns
Month 3	14.2 ± 0.9	13.8 ± 1.1	13.9 ± 1.6	ns
P value^b	<0.001	<0.001	0.008
MUFA (g/d)
Entry	28.2 ± 1.7	26.9 ± 1.8	29.5 ± 5.4	ns
Month 3	19.9 ± 1.4	18.3 ± 0.9	19.8 ± 1.3	ns
P value^b	<0.001	<0.001	0.051
PUFA (g/d)
Entry	11.7 ± 0.9	9.4 ± 0.8	8.7 ± 1.7	ns
Month 3	8.9 ± 0.9	7.7 ± 0.6	9.1 ± 1.3	ns
P value^b	0.029	0.074	0.767
Cholesterol (mg/d)
Entry	293.4 ± 17.4	276.7 ± 18.3	282.6 ± 33.3	ns
Month 3	145.9 ± 9.7	171.1 ± 15.9	141.7 ± 16.2	ns
P value^b	<0.001	<0.001	0.008

Values are mean ± SEM
SFA saturated fatty acids (g/day); MUFA monounsaturated fatty acids(g/day); PUFA polyunsaturated fatty acids (g/day)
^aComparison between genotypes at entry with Western-type diet (WD) and in their response to low-saturated fat, low-cholesterol/Mediterranean-type diet (LFLCD) tested with general linear models. ns: non-significant (P ≥ 0.05)
^bP < 0.05 for comparison between entry and 3-mo within groups (calculated by Student’s t paired test for G/G and G/T and by Wilcoxon test for T/T)

ISSN: 1865-3499