Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein −493 G/T polymorphism and the usual diet in women

Table 3 Subjects fasting biochemical parameters according to MTTP−493 G/T polymorphism at entry on a Western diet (WD)

	G/G (n = 30)	G/T (n = 30)	T/T (n = 9)	P value^a
Cholestanol^b	129.6 ± 9.8	136.4 ± 11.3	199.0 ± 30.0	0.034
Sitosterol^b	103.8 ± 12.5	114.1 ± 15.5	261.1 ± 104.7	0.037
Desmosterol^b	114.2 ± 6.9	106.1 ± 5.7	109.2 ± 4.2	ns
Lathosterol^b	152.8 ± 15.2	142.3 ± 10.3	188.7 ± 21.8	0.081
Cholesterol (mmol/l)	6.62 ± 0.14	6.64 ± 0.19	7.37 ± 0.22	0.106
HDL cholesterol (mmol/l)	1.68 ± 0.09	1.65 ± 0.09	1.65 ± 0.19	ns
LDL cholesterol (mmol/l)	4.26 ± 0.17	4.25 ± 0.19	4.81 ± 0.22	ns
TRL cholesterol (mmol/l)	0.92 ± 0.12	0.98 ± 0.11	1.37 ± 0.31	ns
ApoB-cholesterol (mmol/l)	5.18 ± 0.22	5.15 ± 0.24	6.07 ± 0.47	ns
TRL TG (mmol/l)	0.87 ± 0.11	0.85 ± 0.11	0.86 ± 0.17	ns
TRL PL (mmol/l)	0.29 ± 0.03	0.30 ± 0.03	0.33 ± 0.06	ns
ApoB (g/l)	1.22 ± 0.05	1.33 ± 0.03	1.21 ± 0.09	ns
Insulin (μU/ml)	11.23 ± 1.29	9.21 ± 1.15	8.78 ± 1.66	ns

Values are mean ± SEM. ApoB-cholesterol is the calculated sum of apoB-containing LDL and TRL-cholesterol levels
^aComparison between genotypes at entry tested with general linear models and adjusted for age, menopausal status and BMI. ns non-significant (P ≥ 0.05)
^b10²mmol/mol cholesterol

ISSN: 1865-3499