Table 3 Blood lipids, glucose and insulin before and after diet with isocaloric MCT or LCT fats in 82 subjects (mean ± SD)
From: The effect of FABP2 promoter haplotype on response to a diet with medium-chain triacylglycerols
Day 0 | Day 14 | Difference (%) | P | |
|---|---|---|---|---|
Total cholesterol (mg/dl)* | ||||
A/LCT | 208.6 ± 32.8 | 215.9 ± 36.1 | +7.3 ± 21.9 | 0.12 |
B/LCT | 220.9 ± 33.3 | 217.6 ± 31.3 | −3.3 ± 18.5 | 0.21 |
A/MCT | 212.4 ± 40.2 | 205.3 ± 37.7 | −7.1 ± 17.4 | 0.79 |
B/MCT | 213.8 ± 32.4 | 216.2 ± 29.7 | +0.51 ± 14.0 | 0.78 |
HDL cholesterol (mg/dl) | ||||
A/LCT | 53.9 ± 16.5 | 57.3 ± 19.9 | +3.4 ± 6.4 | 0.025 |
B/LCT | 52.3 ± 9.2 | 55.2 ± 10.4 | +2.8 ± 4.4 | 0.009 |
A/MCT | 55.3 ± 16.9 | 61.0 ± 17.1 | +5.6 ± 6.6 | 0.001§ |
B/MCT | 57.3 ± 18.3 | 59.8 ± 19.8 | +2.4 ± 7.1 | 0.16 |
LDL cholesterol (mg/dl)* | ||||
A/LCT | 137.0 ± 31.4 | 139.7 ± 30.8 | +2.6 ± 18.1 | 0.33 |
B/LCT | 146.0 ± 28.3 | 142.5 ± 28.5 | −3.6 ± 17.4 | 0.31 |
A/MCT | 138.6 ± 35.3 | 131.0 ± 34.3 | −7.7 ± 15.9 | 0.61 |
B/MCT | 142.5 ± 33.7 | 141.6 ± 30.0 | −1.1 ± 15.4 | 0.62 |
Fasting triacylglycerols (mg/dl) | ||||
A/LCT | 131.9 ± 75.5 | 123.9 ± 70.1 | −8.0 ± 52.4 | 0.49 |
B/LCT | 139.7 ± 72.8 | 123.1 ± 56.8 | −16.6 ± 63.9 | 0.26 |
A/MCT | 117.0 ± 63.3 | 102.6 ± 47.1 | −14.4 ± 43.2 | 0.14 |
B/MCT | 107.5 ± 39.2 | 109.7 ± 60.9 | +2.2 ± 36.2 | 0.79 |
Pp triacylglycerols (AUC)b (mg/dl*h) | ||||
A/LCT | 1,559.2 ± 799.6 | 1,503.5 ± 922.2 | −55.7 ± 420.2 | 0.55 |
B/LCT | 1,691.0 ± 783.9 | 1,512.3 ± 471.8 | −178.7 ± 610.3 | 0.21 |
A/MCT | 1,333.8 ± 598.4 | 1,221.0 ± 396.4 | −112.9 ± 426.1 | 0.24 |
B/MCT | 1,404.6 ± 490.7 | 1,355.5 ± 536.5 | −49.0 ± 360.1 | 0.55 |
Fasting glucose (mg/dl)* | ||||
A/LCT | 103.8 ± 8.6 | 97.1 ± 11.9 | −6.7 ± 11.5 | 0.01 |
B/LCT | 100.4 ± 12.0 | 101.5 ± 8.2 | +1.0 ± 8.8 | 0.30 |
A/MCT | 101.7 ± 10.0 | 103.6 ± 12.6 | +1.9 ± 5.3 | 0.92 |
B/MCT | 100.8 ± 9.7 | 101.3 ± 6.9 | +0.5 ± 7.4 | 0.30 |
Ppa glucose (AUC)b (mg/dl*h) | ||||
A/LCT | 524.3 ± 78.9 | 490.3 ± 38.9 | −34.0 ± 75.8 | 0.04 |
B/LCT | 497.5 ± 58.6 | 496.5 ± 54.7 | −1.0 ± 55.9 | 0.88 |
A/MCT | 501.6 ± 60.2 | 488.7 ± 62.6 | −13.0 ± 32.4 | 0.27 |
B/MCT | 516.2 ± 71.9 | 511.5 ± 51.4 | −4.7 ± 38.4 | 0.78 |
Fasting insulin (mU/l) | ||||
A/LCT | 16.3 ± 8.1 | 13.4 ± 5.5 | −2.9 ± 7.6 | 0.10 |
B/LCT | 16.3 ± 8.8 | 15.6 ± 6.9 | −0.70 ± 9.6 | 0.75 |
A/MCT | 13.4 ± 4.6 | 13.9 ± 8.5 | +0.7 ± 5.1 | 0.67 |
B/MCT | 17.7 ± 12.2 | 16.3 ± 12.0 | −1.6 ± 4.9 | 0.16 |
Ppa insulin (AUC)b (mU/l*h) | ||||
A/LCT | 171.7 ± 81.4 | 176.2 ± 75.5 | −4.5 ± 54.0 | 0.70 |
B/LCT | 198.4 ± 80.7 | 223.4 ± 112.0 | −25.0 ± 73.2 | 0.14 |
A/MCT | 185.8 ± 111.3 | 194.8 ± 170.9 | −14.0 ± 94.8 | 0.55 |
B/MCT | 215.9 ± 177.9 | 222.5 ± 222.1 | −10.8 ± 63.9 | 0.46 |
Fasting HOMA-IRc | ||||
A/LCT | 4.1 ± 2.1 | 3.1 ± 1.2 | −1.0 ± 2.1 | 0.04 |
B/LCT | 4.1 ± 2.5 | 3.9 ± 1.9 | −0.2 ± 2.7 | 0.78 |
A/MCT | 3.3 ± 1.3 | 3.6 ± 2.8 | +0.3 ± 1.7 | 0.47 |
B/MCT | 4.5 ± 3.5 | 4.1 ± 3.1 | −0.5 ± 1.3 | 0.14 |
Ppa HOMA-IRc (insulin × glucose AUC) | ||||
A/LCT | 90,077 ± 45,605 | 87,308 ± 40,635 | −2,769 ± 29,909 | 0.68 |
B/LCT | 99,176 ± 41,830 | 114,110 ± 67,814 | 14,934 ± 48,332 | 0.13 |
A/MCT | 96,141 ± 68,489 | 102,083 ± 99,232 | 6,445 ± 49,604 | 0.61 |
B/MCT | 117,769 ± 108,715 | 123,912 ± 136,435 | 5,048 ± 40,537 | 0.58 |
INEFAd (mmol/l) | ||||
A/LCT | −0.5 ± 0.4 | −0.4 ± 0.5 | 0.1 ± 0.7 | 0.49 |
B/LCT | −0.5 ± 0.5 | −0.4 ± 0.3 | 0.2 ± 0.5 | 0.16 |
A/MCT | −0.7 ± 0.7 | −0.7 ± 0.7 | 0.04 ± 0.6 | 0.87 |
B/MCT | −0.4 ± 0.3 | −0.4 ± 0.4 | −0.06 ± 0.6 | 0.67 |