Nutrigenomics approach elucidates health-promoting effects of high vegetable intake in lean and obese men

Pasman, W. J.; van Erk, M. J.; Klöpping, W. A. A.; Pellis, L.; Wopereis, S.; Bijlsma, S.; Hendriks, H. F. J.; Kardinaal, A. F. M.

doi:10.1007/s12263-013-0343-9

Genes & Nutrition

Table 5 Expression changes in obese subjects in response to high vegetable intake compared to low vegetable intake related to inflammation, energy metabolism and adhesion

From: Nutrigenomics approach elucidates health-promoting effects of high vegetable intake in lean and obese men

Definition	Symbol	Probe_Id	Entrez Gene ID	Mean 2log ratio
Energy metabolism
Glutamate-ammonia ligase (glutamine synthetase) (GLUL), transcript variant 3, mRNA	GLUL	ILMN_1765208	2752	0.67	a
Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 3, mRNA	RUNX1T1	ILMN_1710522	862	0.65	a
Peroxisome proliferator-activated receptor gamma, coactivator-related 1 (PPRC1), mRNA	PPRC1	ILMN_1796210	23082	0.65	b
SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2), transcript variant 1, mRNA	SRGAP2	ILMN_1759549	23380	0.57	b
Pyruvate carboxylase (PC), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA	PC	ILMN_1736689	5091	0.44	a
FERM domain containing 6 (FRMD6), transcript variant 2, mRNA	FRMD6	ILMN_2330787	122786	0.42	b
Solute carrier family 25, member 29 (SLC25A29), nuclear gene encoding mitochondrial protein, mRNA	SLC25A29	ILMN_2350801	123096	0.40	b
Solute carrier family 25 (mitochondrial carrier, brain), member 14 (SLC25A14), nuclear gene encoding mitochondrial protein, transcript variant long, mRNA	SLC25A14	ILMN_1743770	9016	0.39	a
Acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain (ACADS), nuclear gene encoding mitochondrial protein, mRNA	ACADS	ILMN_1795104	35	−0.27	b
DNA replication helicase 2 homolog (yeast) (DNA2), mRNA	DNA2	ILMN_2282959	1763	−0.57	b
Protein kinase C, alpha binding protein (PRKCABP), mRNA	PRKCABP	ILMN_1708159	9463	−0.67	a
Apolipoprotein O-like (APOOL), mRNA	APOOL	ILMN_1777483	139322	−0.68	a
Acyl-CoA synthetase medium-chain family member 5 (ACSM5), mRNA	ACSM5	ILMN_1801698	54988	−0.71	a
Estrogen receptor 2 (ER beta) (ESR2), transcript variant b, mRNA	ESR2	ILMN_2390457	2100	−0.74	a
PREDICTED: coiled-coil domain containing 56 (CCDC56), misc RNA	CCDC56	ILMN_1789786	28958	−0.86	a
Component of oligomeric golgi complex 8 (COG8), mRNA	COG8	ILMN_1725246	84342	−1.09	b
Adhesion
Presenilin 1 (Alzheimer disease 3) (PSEN1), mRNA	PSEN1	ILMN_1796669	5663	1.13	a
PREDICTED: p21 (CDKN1A)-activated kinase 2 (PAK2), mRNA	PAK2	ILMN_1659878	5062	0.96	a
Reelin (RELN), transcript variant 1, mRNA	RELN	ILMN_1753005	5649	0.89	b
LIM and senescent cell antigen-like domains 1 (LIMS1), mRNA	LIMS1	ILMN_2381037	3987	0.71	b
Dystonin (DST), transcript variant 1e, mRNA	DST	ILMN_1675992	667	0.70	a
Rap guanine nucleotide exchange factor (GEF) 1 (RAPGEF1), transcript variant 2, mRNA	RAPGEF1	ILMN_1678799	2889	0.50	a
Protocadherin 9 (PCDH9), transcript variant 2, mRNA	PCDH9	ILMN_2379626	5101	0.46	b
Phosphoglucomutase 5 (PGM5), mRNA	PGM5	ILMN_2271149	5239	0.45	b
Periostin, osteoblast specific factor (POSTN), mRNA	POSTN	ILMN_1790761	10631	0.44	b
Claudin 15 (CLDN15), transcript variant 2, mRNA	CLDN15	ILMN_1708267	24146	0.38	a
PREDICTED: p21 (CDKN1A)-activated kinase 2 (PAK2), mRNA	PAK2	ILMN_1676385	5062	0.38	a
Polycystic kidney and hepatic disease 1 (autosomal recessive) (PKHD1), transcript variant 1, mRNA	PKHD1	ILMN_1720034	5314	−0.30	b
Cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) (CELSR1), mRNA	CELSR1	ILMN_1694482	9620	−0.50	b
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3), transcript variant 2, mRNA	AKT3	ILMN_1733598	10000	−0.59	b
Junction plakoglobin (JUP), transcript variant 2, mRNA	JUP	ILMN_2366864	3728	−0.67	a
Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (MLLT4), transcript variant 3, mRNA	MLLT4	ILMN_1746277	4301	−0.77	b
Cadherin-like 24 (CDH24), transcript variant 1, mRNA	CDH24	ILMN_1693928	64403	−0.83	a
Rap guanine nucleotide exchange factor (GEF) 1 (RAPGEF1), transcript variant 1, mRNA	RAPGEF1	ILMN_1695282	2889	−0.93	b
Inflammation
Presenilin 1 (Alzheimer disease 3) (PSEN1), mRNA	PSEN1	ILMN_1796669	5663	1.13	a
Cathepsin C (CTSC), transcript variant 2, mRNA	CTSC	ILMN_1689086	1075	0.78	b
Membrane-associated ring finger (C3HC4) 8 (MARCH8), transcript variant 6, mRNA	MARCH8	ILMN_2341626	220972	0.78	a
Interleukin 7 receptor (IL7R), mRNA	IL7R	ILMN_2342579	3575	0.73	a
Interleukin 8 (IL8), mRNA	IL8	ILMN_2184373	3576	0.66	a
Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C), mRNA	TNFRSF13C	ILMN_1731742	115650	0.63	a
Colony stimulating factor 1 (macrophage) (CSF1), transcript variant 4, mRNA	CSF1	ILMN_1805930	1435	0.52	b
Epstein-Barr virus-induced 3 (EBI3), mRNA	EBI3	ILMN_1802653	10148	0.51	a
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F (APOBEC3F), transcript variant 1, mRNA	APOBEC3F	ILMN_1710726	200316	0.49	b
Neutrophil cytosolic factor 1 (NCF1), mRNA	NCF1	ILMN_1697309	653361	0.38	a
Cathepsin C (CTSC), transcript variant 1, mRNA	CTSC	ILMN_2242463	1075	0.34	b
B and T lymphocyte associated (BTLA), transcript variant 1, mRNA	BTLA	ILMN_1778536	151888	−0.19	a
Chemokine (C-X-C motif) receptor 5 (CXCR5), transcript variant 2, mRNA	CXCR5	ILMN_2337931	643	−0.42	a
Interleukin 1 receptor, type II (IL1R2), transcript variant 2, mRNA	IL1R2	ILMN_1772131	7850	−0.60	b
Lymphocyte transmembrane adaptor 1 (LAX1), mRNA	LAX1	ILMN_1769782	54900	−0.61	a
Serum amyloid A1 (SAA1), transcript variant 1, mRNA	SAA1	ILMN_1701017	6288	−0.68	b
Virus-induced signaling adapter (VISA), mRNA	VISA	ILMN_2131493	57506	−0.69	a
Tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), transcript variant 2, mRNA	TNFSF12	ILMN_1680003	8742	−0.75	a
Serum amyloid A1 (SAA1), transcript variant 1, mRNA	SAA1	ILMN_1808732	6288	−1.29	a

a: p for interaction between intervention and group <0.05; b: p for intervention <0.05. Genes showed consistent expression change in obese subjects (>25 % up or >25 % down in at least 6 subjects)

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ISSN: 1865-3499

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