Table 6 Proteins associated with BMI
Protein_ID | Protein | OMIM ID | logFC | p value | Adj p val | Function |
|---|---|---|---|---|---|---|
LEP | Leptin | 164160 | 1,447.51 | 8.15E−12 | 9.20E−09 | Role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure |
GHR | Ghrelin | 605353 | 43.80 | 3.63E−08 | 2.05E−05 | Involved in regulating growth hormone release. Derived from a preproghrelin, which also generates a second peptide called obestatin involved in satiety and decreased food intake |
CD70 | TNF ligand member 7 | 602840 | 37.96 | 3.79E−05 | 0.010705 | Potent activator of T cells in vivo |
CRP | C-reactive protein | 123260 | 1,894.64 | 1.18E−05 | 0.004431 | Marker of low-grade inflammation—may have a role in the pathogenesis of atherosclerotic lesions in humans |
APCS | Amyloid P component | 104770 | 751.46 | 5.37E−05 | 0.012127 | Participates in pathogenesis of amyloidosis in vivo |
LGALS4 | Lectin, galactoside binding | 602518 | 9.278 | 0.000398 | 0.053566 | Antibacterial lysis factor expressed in the intestine |
CCDC80 | Upregulated in Bombesin-deficient mice | 608298 | 37.11 | 0.000494 | 0.053566 | May play a role in energy metabolism and the regulation of body weight |
F9 | Coagulation factor IX | 300746 | 122.52 | 0.000569 | 0.053566 | Factor IXa activates factor X as part of an intrinsic activating complex that also consists of factor VIIIa |
DSC3 | Desmocollin 3 | 600271 | 7.18 | 0.000523 | 0.053566 | Intercellular adhesion molecules belonging to the cadherin superfamily |
APOE | Apolipoprotein E | 107741 | 663.39 | 0.000519 | 0.053566 | Apolipoprotein E mediates the presentation of serum-borne lipid antigens. Association with multiple chronic diseases |
LGALS3BP | Lectin, galactoside binding, soluble, binding protein | 600626 | 30.36 | 0.000215 | 0.040546 | Stimulates the host immune system via induction of IL2 and possibly other cytokines |
HSD17B1 | 17-beta-hydroxysteroid dehydrogenase | 109684 | 21.05 | 0.000616 | 0.053566 | Interconversion of estrone (E1) and estradiol (E2) as well as the interconversion of androstenedione and testosterone |
PDE11A | Phosphodiesterase 11A | 604961 | 27.00 | 0.000575 | 0.053566 | Catalyze the hydrolysis of 3′,5′-cyclic nucleotides to the nucleoside 5′-monophosphates. Pde11a knockout mice show subtle behavioral deficits, hyperactivity in an open field, impaired social odor recognition memory, and social avoidance |
RTN4R | Reticulon 4 receptor | 605566 | 28.38 | 0.001119 | 0.090252 | Central roles in limiting axonal regeneration in CNS injury |