Meat-derived carcinogens, genetic susceptibility and colorectal adenoma risk

Genes & Nutrition

Table 3 Colorectal adenoma risk associated with genetic factors

Gene	rs	Genotype category	Functional effect	N ^a	Adjusted OR^b (95 % CI) ^b	p
CYP1A2	762551	AC/CC	Referent	99/64	Referent	0.36
CYP1A2	762551	AA	Higher bioactivation	108/54	1.28 (0.75–2.17)	0.36
CYP1B1	10012; 1056827	CC + GG	Referent	113/48	Referent	<0.01
CYP1B1	10012; 1056827	CG/GG + GT/TT	Higher bioactivation	79/59	2.28 (1.29–4.03)	<0.01
NAT2	1041983	TT	Intermediate/Slow	109/57	Referent	0.45
NAT2	1041983	CC/CT	Rapid	99/61	1.22 (0.73–2.06)	0.45
XPA	1800975	CT/TT	Referent	102/59	Referent	0.24
XPA	1800975	CC	Lower DNA repair	101/55	0.79 (0.46–1.34)	0.24
XPD	13181;1799793	AA + GG	Referent	102/54	Referent	0.71
XPD	13181;1799793	CC/CA + AA/GA	Lower DNA repair	106/64	1.11 (0.66–1.87)	0.71
XRCC1	25487	GG	Referent	87/56	Referent	0.80
XRCC1	25487	AA/AG	Lower DNA repair	116/58	0.94 (0.55–1.59)	0.80
ADPRT	1136410	TT	Referent	141/78	Referent	0.96
ADPRT	1136410	CC/CT	Lower DNA repair	67/40	1.02 (0.58, 1.77)	0.96
XPC	2228001	AA	Referent	84/33	Referent	0.07
XPC	2228001	CC/CA	Lower DNA repair	124/84	1.68 (0.97–2.90)	0.07
XRCC3	861539	CC	Referent	74/47	Referent	0.33
XRCC3	861539	TT/TC	Lower DNA repair	129/67	0.76 (0.44–1.31)	0.33

Bolded text indicate statistically significant relationships
^a N for non-events/N for events
^bAdjusted for sex, smoking status, fruit and vegetable intake, dietary fiber intake and biomarker levels of albumin and folate

ISSN: 1865-3499