Table 1 Expert’s knowledge-based processes and associated markers as defined by the BIOCLAIMS consortium including main results from the integrated network analysis
From: White adipose tissue reference network: a knowledge resource for exploring health-relevant relations
Name | Process | Tissue | Nr. studies measured | Significant across studies | Consistent fold-change | Nr. Seed node neighbors |
|---|---|---|---|---|---|---|
Adipocyte area | Adipose expandability | Adipose | 0 | – | – | 0 |
Adiponectin | Adipose expandability | Blood | 0 | – | – | 1 |
Adipose mass MRI | Adipose expandability |  | 0 | – | – | 0 |
Adipose tissue mass | Adipose expandability | Â | 6 | Yes | Yes | 6 |
Brown fat mass | Adipose expandability | Â | 3 | Yes | Yes | 5 |
Epididymal adipose mass | Adipose expandability | Â | 5 | Yes | Yes | 3 |
Leptin | Adipose expandability | Blood | 0 | – | – | 5 |
Leptin Adiponectin ratio | Adipose expandability | Blood | 5 | Yes | Yes | 2 |
MEST1 | Adipose expandability | Adipose | 4 | Yes | Yes | 0 |
Subcutaneous adipose mass# | Adipose expandability | Â | 1 | No | No | 0 |
Visceral adipose mass | Adipose expandability | Â | 4 | No | Yes | 12 |
Acadvl# | Metabolic state | Adipose | 7 | No | Yes | 1 |
Acc | Metabolic state | Adipose | 7 | Yes | Yes | 2 |
Acyl carnitines | Metabolic state | Blood | 0 | – | – | 0 |
Adiponectin | Metabolic state | Adipose | 7 | No | No | 6 |
ATGL | Metabolic state | Adipose | 7 | No | No | 7 |
BCAA | Metabolic state | Blood | 0 | – | – | 0 |
CPT1 (PBMC)# | Metabolic state | PBMC | 2 | Yes | No | 0 |
CPT1a | Metabolic state | Adipose | 7 | Yes | Yes | 5 |
Cpt1b | Metabolic state | Adipose | 6 | No | No | 5 |
Dgat2# | Metabolic state | Adipose | 7 | No | No | 1 |
FABP4 | Metabolic state | Adipose | 7 | No | Yes | 3 |
FABPpm# | Metabolic state | Adipose | 7 | No | No | 1 |
FAS | Metabolic state | Adipose | 7 | No | No | 9 |
FASN | Metabolic state | Adipose | 7 | Yes | Yes | 7 |
FASN (PBMC) | Metabolic state | PBMC | 2 | Yes | Yes | 0 |
GLUT4 | Metabolic state | Adipose | 7 | Yes | Yes | 6 |
Gpat | Metabolic state | Adipose | 7 | No | No | 3 |
GyK# | Metabolic state | Adipose | 7 | No | No | 0 |
Hsl | Metabolic state | Adipose | 7 | No | No | 5 |
HSL (PBMC)# | Metabolic state | PBMC | 1 | No | Yes | 0 |
INSR | Metabolic state | Adipose | 7 | No | No | 9 |
IRS1 | Metabolic state | Adipose | 7 | No | No | 15 |
Lactate | Metabolic state | Blood | 0 | – | – | 0 |
LDHa | Metabolic state | Adipose | 4 | Yes | Yes | 4 |
LepR | Metabolic state | Adipose | 7 | No | No | 3 |
Lpl | Metabolic state | Adipose | 7 | Yes | Yes | 10 |
Lysophosphatidylinositols (plasma) | Metabolic state | Blood | 0 | – | – | 0 |
PDK | Metabolic state | Adipose | 7 | Yes | Yes | 3 |
PFK | Metabolic state | Adipose | 7 | Yes | Yes | 0 |
PGC1a | Metabolic state | Adipose | 7 | No | Yes | 7 |
PKM | Metabolic state | Adipose | 4 | Yes | Yes | 6 |
Ppara | Metabolic state | Adipose | 7 | No | No | 16 |
Resistin | Metabolic state | Blood | 0 | – | – | 1 |
RXRB (PBMC) | Metabolic state | PBMC | 2 | Yes | Yes | 0 |
SIRT1 | Metabolic state | Adipose | 4 | No | No | 26 |
Tyrosine hydroxylase level# | Metabolic state | Adipose | 6 | No | No | 1 |
UCP2 | Metabolic state | Adipose | 7 | Yes | Yes | 3 |
Visfatin | Metabolic state | Blood | 0 | – | – | 0 |
Mito density (cardiolipin) | Oxidative capacity | Adipose | 0 | – | – | 0 |
Mito density (citrate synthase level) | Oxidative capacity | Adipose | 0 | – | – | 0 |
Mito density (EM) | Oxidative capacity | Adipose | 0 | – | – | 0 |
Mito density (mt/nDNA) | Oxidative capacity | Adipose | 2 | Yes | Yes | 2 |
Uncoupled oxygen consumption | Oxidative capacity | Adipose | 0 | – | – | 0 |
Aconitase/citrate synthase activity | Oxidative stress | Adipose | 0 | – | – | 0 |
SOD1 | Oxidative stress | Adipose | 7 | Yes | Yes | 8 |
SOD2 | Oxidative stress | Adipose | 7 | Yes | No | 7 |
TRXRD2 | Oxidative stress | Adipose | 0 | – | – | 0 |
Adam8 | Tissue inflammation | Adipose | 7 | Yes | Yes | 0 |
Cd11c | Tissue inflammation | Adipose | 4 | Yes | Yes | 2 |
Cd163 | Tissue inflammation | Adipose | 7 | No | No | 3 |
Glut1 | Tissue inflammation | Adipose | 7 | No | No | 5 |
Gpx1 | Tissue inflammation | Adipose | 0 | – | – | 2 |
Hif1a | Tissue inflammation | Adipose | 7 | No | No | 38 |
Il10 | Tissue inflammation | Adipose | 4 | No | No | 21 |
Il1b | Tissue inflammation | Adipose | 0 | – | – | 0 |
Il6 | Tissue inflammation | Adipose | 4 | No | No | 50 |
Mgl2 | Tissue inflammation | Adipose | 0 | – | – | 0 |
Mrc1 | Tissue inflammation | Adipose | 7 | Yes | Yes | 1 |
Nos2 | Tissue inflammation | Adipose | 3 | No | No | 11 |
Ppargc1b# | Tissue inflammation | Adipose | 5 | No | No | 1 |
Stat6 | Tissue inflammation | Adipose | 7 | No | No | 5 |
Tnf | Tissue inflammation | Adipose | 4 | Yes | Yes | 48 |
Vegfa | Tissue inflammation | Adipose | 7 | No | Yes | 48 |
Vhl | Tissue inflammation | Adipose | 7 | No | Yes | 28 |