Table 2 List of the top genes associated with the GGH-specific altered expression in the GGH-modulated HCT116 colon cancer cells
Gene symbol | Fold change (vs. control) | Description | Accession | |
|---|---|---|---|---|
GGH overexpression | GGH inhibition | |||
Downregulated in GGH overexpression and upregulated in GGH inhibition | ||||
POLE4 | −6.53 | 1.59 | Polymerase (DNA-directed), epsilon 4 (p12 subunit) | NM_019896.2 |
PVRL3* | −3.86 | 1.41 | Poliovirus receptor-related 3 | NM_015480.1 |
TNFRSF6B* | −2.61 | 2.49 | Tumor necrosis factor receptor superfamily, member 6b, decoy | NM_032945.2 |
PDE4B | −1.77 | 3.24 | Phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | NM_002600.3 |
TRIM33 | −1.69 | 1.33 | Tripartite motif-containing 33 | NM_015906.3 |
PYGL | −1.68 | 1.37 | Phosphorylase, glycogen, liver | NM_002863.3 |
ALG6 | −1.59 | 1.66 | Asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase) | NM_013339.2 |
MTAP | −1.59 | 1.36 | Methylthioadenosine phosphorylase | NM_002451.3 |
MCOLN2 | −1.54 | 1.51 | Mucolipin 2 | NM_153259.2 |
SACS | −1.52 | 1.52 | Spastic ataxia of Charlevoix-Saguenay (sacsin) | NM_014363.3 |
Upregulated in GGH overexpression and downregulated in GGH inhibition | ||||
ANXA10 | 1.62 | −6.85 | Annexin A10 | NM_007193.3 |
TACSTD2 | 1.37 | −2.38 | Tumor-associated calcium signal transducer 2 | NM_002353.1 |
TMEM200A | 1.67 | −1.89 | Transmembrane protein 200A | NM_052913.2 |
UPP1 | 1.90 | −1.79 | Uridine phosphorylase 1 | NM_003364.2 |
PBX1 | 1.68 | −1.73 | Pre-B-cell leukemia homeobox 1 | NM_002585.1 |
PHF19 | 1.37 | −1.62 | PHD finger protein 19 | NM_001009936.1 |
RERG | 2.97 | −1.49 | RAS-like, estrogen-regulated, growth inhibitor | NM_032918.1 |
IRS1 | 1.38 | −1.47 | Insulin receptor substrate 1 | NM_005544.1 |
PPARG | 1.37 | −1.39 | Peroxisome proliferator-activated receptor gamma | NM_015869.4 |
RRP7A | 1.32 | −1.36 | Ribosomal RNA processing 7 homolog A (S. cerevisiae) (RRP7A), mRNA | NM_015703.3 |