Table 3 List of the top genes associated with the GGH-specific altered expression in the GGH-modulated MDA-MB-435 breast cancer cells
Gene symbol | Fold change (vs. control) | Description | Accession | |
|---|---|---|---|---|
GGH overexpression | GGH inhibition | |||
Downregulated in GGH overexpression and upregulated in GGH inhibition | ||||
SPP1* | −4.51 | 5.88 | Secreted phosphoprotein 1 | NM_001040058.1 |
PRSS7* | −1.94 | 4.66 | Protease, serine, 7 (enterokinase) | NM_002772.1 |
TYR | −31.95§ | 4.07 | Tyrosinase (oculocutaneous albinism IA) | NM_000372.4 |
CYB5R2 | −1.34 | 3.05 | Cytochrome b5 reductase 2 | NM_016229.3 |
BCHE* | −4.82 | 2.31§ | Butyrylcholinesterase | NM_000055.2 |
ADM | −2.63 | 2.31 | Adrenomedullin | NM_001124.1 |
TMEM166 | −3.05 | 2.07 | Transmembrane protein 166 | NM_032181.1 |
ORC5L | −1.35 | 2.07 | Origin recognition complex, subunit 5-like (yeast) | NM_002553.2 |
PNLIPRP3 | −1.34 | 2.05 | Pancreatic lipase-related protein 3 | NM_001011709.1 |
DYNC1I1 | −5.83 | 2.03 | Dynein, cytoplasmic 1, intermediate chain 1 | NM_004411.3 |
Upregulated in GGH overexpression and downregulated in GGH inhibition | ||||
CTHRC1* | 1.77 | −4.44§ | Collagen triple helix repeat containing 1 | NM_138455.2 |
NNMT | 4.80§ | −3.24 | Nicotinamide N-methyltransferase | NM_006169.2 |
HLA-DOA | 1.44 | −3.09 | Major histocompatibility complex, class II, DO alpha | NM_002119.3 |
FSCN1 | 3.31 | −3.03 | Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) | NM_003088.2 |
CDC42EP5 | 3.76§ | −2.53§ | CDC42 effector protein (Rho GTPase binding) 5 | NM_145057.2 |
CHN1 | 2.79§ | −2.30 | Chimerin (chimaerin) 1 | NM_001025201.1 |
SLC2A3 | 1.94 | −2.24 | Solute carrier family 2 (facilitated glucose transporter), member 3 | NM_006931.1 |
HLA-DRB6 | 2.91 | −2.20 | Major histocompatibility complex, class II, DR beta 6 (pseudogene) | NR_001298.1 |
HLA-DQA1 | 6.26 | −2.19 | PREDICTED: major histocompatibility complex, class II, DQ alpha 1, transcript variant 10 | XM_936128.2 |
PHF21A | 1.75 | −2.11 | PHD finger protein 21A | NM_016621.2 |
C21orf34 | 1.39 | −2.11 | Chromosome 21 open reading frame 34 | NM_001005734.1 |
S100A4* | 13.13§ | −2.10 | S100 calcium-binding protein A4 | NM_019554.2 |