Fig. 3
Association network 1 (ball and stick) of aorta proteins influenced by B vitamin and fat intake in ApoE null mice. Association networks between biochemical biomarkers and protein expression were displayed using Cytoscape software (version 2.8.3; http://www.cytoscape.org). Lines connecting proteins and biomarkers indicate a correlation with R > 0.3 or <−0.3. ACH adventitial total cholesterol, AHDL adventitial high-density lipoprotein, AMF adventitial monounsaturated fatty acid, ANF adventitial non-esterified fatty acid, APF adventitial polyunsaturated fatty acid, ASF adventitial saturated fatty acid, ATF adventitial total fat, ATG adventitial triglyceride, B 12 vitamin B12, HDL high-density lipoprotein, Hcy homocysteine, LDL low-density lipoprotein, SAH S-adenosylhomocysteine, SAM S-adenosylmethionine, SAM: SAH S-adenosylmethionine: S-adenosylhomocysteine ratio, TC total cholesterol, TG triglyceride. Spot number and protein name: 409, serotransferrin; 410, serotransferrin; 411, glyceraldehyde-3-phosphate dehydrogenase; 438, moesin; 468, 78 kDa glucose-regulated protein; 473, heat shock protein 1β, 479, WD repeat-containing protein 1; 503, stress-induced-phosphoprotein 1; 507, transforming growth factor β-induced; 524, pyruvate kinase isozymes M1/M2; 557, fibrinogen Β β polypeptide isoforms; 582, protein-glutamine gamma-glutamyltransferase 2; 604, glutamate dehydrogenase 1; 682, serotransferrin; 711, isovaleryl-CoA dehydrogenase; 752, vimentin; 772, aldose reductase; 812, electron transfer flavoprotein subunit α; 813, S-formylglutathione hydrolase; 829, annexin A1; 875, Rho GDP dissociation inhibitor 1; 887, glutathione S-transferase Mu 1; 890, collagen α-1(XVIII) chain; 909, GTP-binding nuclear protein Ran; 912, isocitrate dehydrogenase; 924, peroxiredoxin-2; 938, vimentin; 1,060, transgelin; 1,085, myosin regulatory light polypeptide 9; 1,125, transgelin; 1,126, myosin light polypeptide 6; 1,169, dermatopontin