Genes & Nutrition

Table 2 Correlation analyses of B vitamin, lipid status and atherosclerotic plaque formation in ApoE null mice

From: Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice

Biomarker		Correlation	P value
Plaque associations
Plaque abundance	Plasma HDL	0.763	8E−12
Plaque abundance	Plasma LDL	0.736	5E−10
Plaque abundance	Plasma total cholesterol	0.708	1.3E−08
Plaque abundance	Adventitia total cholesterol	0.586	2.1E−06
Plaque abundance	Adventitia HDL	0.446	0.00055
Plaque abundance	Plasma TG	−0.427	0.00106
Plaque abundance	Adventitia SATFA	0.374	0.00526
Plaque abundance	Plasma B₁₂	−0.271	0.04303
B vitamin status and lipid metabolism
Adventitia total cholesterol	Plasma B₁₂	−0.339	0.00802
Adventitia SATFA	Whole blood B₁₂	−0.632	1.3E−07
Adventitia SATFA	Plasma homocysteine	0.534	1.9E−05
Adventitia SATFA	Plasma B₁₂	−0.502	6.8E−05
Adventitia SATFA	Plasma folate	−0.396	0.00231
Adventitia MUFA	Plasma homocysteine	−0.564	4.8E−06
Adventitia MUFA	Plasma B₁₂	0.456	0.00037
Adventitia MUFA	Whole blood B₁₂	0.445	0.00052

Analysis of associations between blood B vitamin status markers and blood, vascular lipids and plaque formation were carried out for all mice in all treatment groups using Pearson’s correlation coefficients. Biomarker and strength of associations (Pearson’s correlation coefficient; positive and negative) are shown together with the corresponding P value. B ₁₂ vitamin B₁₂, HDL high-density lipoprotein, LDL low-density lipoprotein, MUFAs monounsaturated fatty acids, PUFAs polyunsaturated fatty acids, NEFA non-esterified fatty acids, SATFAs saturated fatty acids

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