Fig. 2
The hallmarks of aging. Aging hallmarks are common molecular processes and phenotypic alterations that define cellular senescence and/or systemic aging across evolution. The highly conserved aging traits may act independently or coordinately with exogenous or endogenous stress factors, including specific dietary habits. Given that neither genetic modifications nor caloric restriction can be applied in humans; the understanding of how nutrition alters genome (nutrigenomics) and consequently proteome expression patterns, is a critical parameter for the design of nutritional interventions aiming to increase healthy aging