Group/pathway | No. of DMGs (%)a | Selected genes | P value |
---|---|---|---|
FA-D/FA-N | |||
 cGMP-PKG signaling pathwayb | 29/167 (17.37) | Gucy1a2, Gucy1a3, Adcy4, Calml3, Ednra, Myh7, Myl9, Mylk2, Pde2a (hypermethylated), Adcy3, Adcy7, Cacna1d, Irs2, Irs3, Adcy1, Adcy5, Adrb1, Atp2b4, Bad, Gna11, Gna13, Irs1, Itpr3, Kcnmb4, Mrvi1, Pde2a, Pde3b, Pde5a, Ppp1ca, Vdac3 (hypomethylated) | 7.83E−04 |
 Gap junctionb | 15/88 (17.05) | Gucy1a2, Gucy1a3, Adcy4, Egfr (hypermethylated), Adcy3, Adcy7, Adcy1, Adcy5, Adrb1, Cdk1, Gna11, Itpr3, Pdgfc, Sos1, Tubb6 (hypomethylated) | 1.61E−02 |
 Calcium signaling pathwayb | 27/188 (14.36) | Grin2d, Adcy4, Calml3, Cckbr, Ednra, Egfr, Erbb3, Grin1, Mylk2, P2rx1, Ptger1, Tnnc2, Trhr (hypermethylated), Adcy3, Adcy7, Cacna1d, Cacna1h, Gnal, Phkg2, Adcy1, Adrb1, Atp2b4, Gna11, Itpr3, Plcd3, Stim2, Vdac3 (hypomethylated) | 1.63E−02 |
 mTOR signaling pathway | 26/157 (16.56) | Atp6v1f, Flcn, Rps6ka1, Rraga, Slc3a2, Wnt10a, Wnt5b, Wnt7b (hypermethylated), Atp6v1b2, Atp6v1e2, Atp6v1h, Cab39, Ddit4, Dvl3, Eif4e2, Igf1r, Irs1, Prkaa1, Pten, Rps6ka3, Rragd, Sos1, Stk11, Ulk2, Wnt3, Wnt7a (hypomethylated) | 2.86E−03 |
 Rap1 signaling pathway | 30/217 (13.82) | Actb, Adcy4, Calml3, Egfr, Fgf14, Fgf21, Fgfr1, Grin1, Mapk12, Prkci, Rapgef6, Skap1, Vegfb (hypermethylated), Adcy1, Adcy3, Adcy5, Adcy7, Efna2, Fgf12, Fgf20, Fgfr2, Igf1r, Itgb1, Kitlg, Map2k3, Ngfr, Pdgfc, Pfn1, Rasgrp3, Sipa1l2 (hypomethylated) | 1.93E−02 |
 Notch signaling pathway | 10/52 (19.23) | Aph1b, Notch1, Psen1 (hypermethylated), Ctbp2, Dtx3l, Dvl3, Hes5, Jag1, Lfng, Notch2 (hypomethylated) | 2.09E−02 |
 Endocytosis | 35/263 (13.31) | Ap2m1, Arpc4, Chmp1a, Chmp2a, Chmp5, Cyth2, Dnm3, Egfr, Folr1, Gbf1, Grk5, Iqsec3, Kif5a, Nedd4l, Prkci, RT1-M10-1, Sh3kbp1, Stam2, Stambp (hypermethylated), Arf1, Arf5, Arf6, Capza2, Cxcr4, Fgfr2, Git2, Igf1r, Pld2, Rab11fip1, Sh3glb2, Smad2, Smad3, Snx2, Spg20, Vps37a (hypomethylated) | 2.09E−02 |
 Neurotrophin signaling pathway | 19/124 (15.32) | Calml3, Irak3, Irak4, Kidins220, Mapk12, Ntf3, Ntrk1, Psen1, Rps6ka1, Tp73 (hypermethylated), Arhgdia, Bad, Irs1, Ngfr, Ntrk2, Ptpn11, Rela, Rps6ka3, Sos1 (hypomethylated) | 2.17E−02 |
FA-S/FA-N | |||
 cGMP-PKG signaling pathwayb | 25/167 (14.97) | Adcy3, Adcy7, Gucy1a2, Irs2, Calm3, Cngb1, Mapk3, Nfatc4, Ppp3r2 (hypermethylated), Cacna1d, Gucy1a3, Irs3, Adcy2, Adcy6, Adra2c, Atp1b1, Atp1b3, Fxyd2, Gata4, Kcnma1, Map2k2, Mylk, Nos3, Prkce, Slc8a2 (hypomethylated) | 2.38E−04 |
 Gap junctionb | 14/88 (15.91) | Adcy3, Adcy7, Gucy1a2, Csnk1d, Hras, Htr2c, Mapk3, Mapk7, Tuba3b, Tuba4a (hypermethylated), Gucy1a3, Adcy2, Adcy6, Map2k2 (hypomethylated) | 3.07E−03 |
 Calcium signaling pathwayb | 27/188 (14.36) | Adcy3, Adcy7, Cacna1h, Phkg2, Calm3, Camk2a, Drd5, Grpr, Htr2c, P2rx4, P2rx6, Phka2, Ppp3r2, Tacr1 (hypermethylated), Cacna1d, Gnal, Grin2d, Adcy2, Camk2d, Erbb4, Gna14, Htr5b, Ltb4r2, Mylk, Nos3, P2rx5, Slc8a2 (hypomethylated) | 2.73E−04 |
 MAPK signaling pathway | 37/298 (12.42) | Cacna1h, Dusp4, Dusp8, Dusp9, Fgf16, Fgf4, Hras, Hspa8, Hspb1, Il1rap, Map4k3, Mapk3, Mapk7, Myc, Myd88, Pla2g4b, Ppp3r2, Rac2 (hypermethylated), Cacna1d, Cacng6, Cdc25b, Dusp3, Fas, Fgf20, Ikbkb, Il1r1, Kitlg, Map2k2, Map3k1, Map3k12, Map3k13, Map4k4, Mapk8ip1, Tgfa, Tgfb1, Traf2, Vegfa (hypomethylated) | 4.51E−04 |
 ErbB signaling pathway | 15/89 (16.85) | Camk2a, Hras, Mapk3, Myc, Pak6, Rps6kb1, Shc2 (hypermethylated), Areg, Camk2d, Erbb4, Map2k2, Rps6kb2, Shc1, Shc3, Tgfa (hypomethylated) | 1.22E−03 |
 Glutamatergic synapse | 14/116 (12.07) | Adcy3, Adcy7, Grm6, Mapk3, Pla2g4b, Ppp3r2, Slc17a8, Slc38a1 (hypermethylated), Adcy2, Adcy6, Cacna1d, Grin2d, Shank1, Shank2 (hypomethylated) | 3.20E−02 |
 Neuroactive ligand-receptor interaction | 29/291 (9.97) | Chrna2, Drd5, Gabra5, Gabrd, Gabre, Gcgr, Gpr50, Grm6, Grpr, Htr1a, Htr2c, P2rx4, P2rx6, Prss2, Pth1r, Sstr1, Tacr1, Uts2r (hypermethylated), Adra2c, Chrna1, Glp2r, Grid1, Grin2d, Htr5b, Ltb4r2, Mc2r, P2rx5, Prlhr, Ptgir (hypomethylated) | 3.44E−02 |