Fig. 5From: Prebiotic/probiotic supplementation resulted in reduced visceral fat and mRNA expression associated with adipose tissue inflammation, systemic inflammation, and chronic disease riskDifferential expression of mRNA (Log2 fold difference from placebo) grouped according to biological pathway. A Adipose tissue inflammation. B Systemic inflammation, and C chronic disease. The prebiotic + probiotic supplement (PreticX® Xylooligosaccharide; 0.8 g/day; AIDP; City of Industry, CA, USA; MegaDuo® Bacillus subtilis HU58 and Bacillus coagulans SC-208; 3 billion CFU/day; Microbiome Labs, LLC; Phoenix, AZ, USA) was compared to a placebo (rice flour) group. A random, double-blind approach was used to assign participants to each condition. The dotted horizontal line represents no change relative to placebo at a given timepoint. Values above the dotted horizontal line are an increase in differential expression relative to placebo, and values below the dotted horizontal line represent a decrease in differential expression relative to placebo. The size of each spot is proportional to the Log2 change in differential mRNA expression from placeboBack to article page