Table 2 MR analysis results of exposure (including vitamin D intake and 25-hydroxyvitamin D) and irritable bowel syndrome (IBS)
Exposure | MR Method | No.SNP | β | SE | OR(95%CI) | P | Ajusted-P |
|---|---|---|---|---|---|---|---|
Vitamin D intake | MR Egger | 53 | − 0.0664 | 0.1173 | 0.9357 (0.7434,1.1778) | 0.57430 | – |
Weighted median | − 0.1469 | 0.1082 | 0.86338 (0.70048,1.0641) | 0.17458 | – | ||
IVW(fixed effects) | − 0.09576 | 0.075005 | 0.90867 (0.76941,1.0731) | 0.20168 | 0.4033 | ||
Maximum likelihood | − 0.0959 | 0.0752 | 0.90859 (0.7840,1.0528) | 0.2023 | – | ||
Penalized-weighted median | − 0.14693 | 0.1084 | 0.86335 (0.6964,1.0703) | 0.1741 | – | ||
MR-PRESSO | − 0.09177 | 0.0845 | 0.9123 (0.8167,1.0192) | 0.2825 | – | ||
25-hydroxyvitamin D | MR Egger | 92 | − 0.126 | 0.139 | 0.881 (0.671,1.158) | 0.367 | – |
Weighted median | − 0.189 | 0.140 | 0.828 (0.626,1.094) | 0.175 | – | ||
IVW (fixed effects) | − 0.184 | 0.0e1 | 0.832 (0.696,0.995) | 0.0436 | 0.1744 | ||
Maximum likelihood | − 0.185 | 0.091 | 0.832 (0.695,0.994) | 0.0433 | – | ||
Penalized-weighted median | − 0.189 | 0.135 | 0.828 (0.630,1.087) | 0.160 | – | ||
MR-PRESSO | − 0.17332 | 0.0934 | 0.8408 (0.7527,0.9393) | 0.0667 | – |