Genome-wide association study of serum magnesium in type 2 diabetes

Genes & Nutrition

Table 2 Base model of associations between serum Mg²⁺ concentrations and the lead regional genome-wide significant SNPs.

SNP	chr	Location	Allele frequency^a	Function	Coded^b	Closest gene	% Variance explained	Beta (mmol/L)	SE	P
rs7894336	10	8026609	0.53	Intronic	C>T	TAF3	0.54	− 0.011	0.002	2.9E−9
rs11264341	1	155151493	0.47	Intronic	C>T	TRIM46	0.44	0.010	0.002	2.9E−7
rs10019833	4	77357592	0.37	Intronic	T>C	SHROOM3	0.41	0.010	0.002	4.0E−7
rs2270860	6	43270151	0.31	Synonymous	C>T	SLC22A7	0.28	− 0.010	0.002	1.0E−6

Base model is adjusted for age, sex, and PC 1-3
chr = chromosome, Mg²⁺ = magnesium ion, PC = principal component, SE = standard error, SNP = single nucleotide polymorphism
^aAllele frequency is for European populations, according to the gnomAD database v3.1.2. [27]
^bCoded alleles are inversely associated with serum Mg²⁺

ISSN: 1865-3499