Table 4 Evidence of functional relationships between vitamin B and long noncoding RNAs (lncRNAs)
From: Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs
Compound | LncRNA(s) studied in the project | System: Patients / cell line(s) / animal model | Highlighted lncRNA(s)/pathway(s)/target(s)/ partners/ interactions | Disease context/ implication for human disease | Main result(s): | Ref |
|---|---|---|---|---|---|---|
Vitamin B metabolism-associated disorders in prenatal and early childhood | ||||||
Folic acid and B12 | KCNQ1OT1 | C57BL/6 mouse model (Blood, serum [to assess biochemical parameters] Placenta and fetal tissues [to assess expression and epigenetics) | _ | Effect of folic acid and B12 deficiency on offspring | The epigenetic reprograming of insulin‐like growth factor type‐II receptor (IGF2R) and lncRNA KCNQ1OT1 is associated with different dietary combinations of folic acid and B12 in mice | [89] |
Vitamin B groups | H19, MEG3 | 496 infant-mother pairs | _ | Effects of maternal vitamin B12, B6, and homocysteine consumption during pregnancy on fetal growth and development | • Association of maternal B12 and PLP concentration with 3-year weight gain was reported Association of maternal PLP with methylation status of MEG3 differentially methylated region was reported | [90] |
Vitamin B1 and B12 | MALAT1 | Cerebral palsy model in rats Cell culture: Mouse N2A neuroblastoma cells | MALAT1/miR-1/BDNF/PI3K/Akt pathway | Cerebral Palsy (CP) | The protective effect of vitamin B1 and B12 on neuron injury is exerted through modulation of MALAT1/miR-1 axis | [93] |
Vitamin B group & folate metabolism | RNA sequencing of Ang II exposed SH-SY5Y cells (432 upregulated & 389 downregulated lncRNA) | Ang II exposure in SH-SY5Y cells (human neuroblastoma cell line) | _ | Ang II-related neuronal damage | Analysis of DE lncRNAs highlighted vitamin B group metabolism, glycosphingolipid biosynthesis, apoptosis, and the neurotrophin signalling pathway | [94] |
Vitamin B metabolism-associated disorders during adulthood | ||||||
Pyridoxal phosphate and pyridoxamine phosphate, folic acid, vitamin C | Blood transcriptomic of TB patients vs controls (To find differentially expressed lncRNAs, mRNAs, and miRNAs) | Bioinformatics: (Computational analysis of public datasets) | OSBPL10-AS1/hsa-miR-485-5p/SLC23A2, | Pulmonary Tuberculosis (TB) | LncRNA OSBPL10-AS1, miRNA hsa-miR-485-5p, mRNA SLC23A2, pyridoxal phosphate, pyridoxamine phosphate, and folic acid are co-regulated blood biomarkers for TB | [95] |
Vitamin B6 | MALAT1 | 127 pairs of paraffin embedded breast IDC tissues and adjacent normal tissues, 105 benign fibroadenomas, MCF12A, MCF-7 and MDA-MB231 | MALAT1/miR-216b-5p/PNPO axis | Breast Invasive Ductal Carcinoma (IDC) | The study identified a regulatory axis of MALAT1/miR-216b-5p/PNPO with potential to be therapeutically targeted | [96] |
Vitamin B12 | AspocR lncRNA | Listeria monocytogenes | _ | L. monocytogenes and enterobacterial pathogenesis | Study showed that riboswitches modulate the expression of noncoding RNAs | [97] |
Vitamin B6 | Sense lncRNA AK370814 | Seeds ((Hasat, Beysehir 99, Konevi 98 and Tarm 92) in response to salinity application for 3 days post-germination) | _ | Germination under salinity condition | This lncRNA has been associated with vitamin B6 salvage pathway | [98] |