Table 6 Evidence on specific functional relationships between vitamin metabolism pathways and long noncoding RNAs (lncRNAs)
From: Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs
Compound | LncRNA(s) studied in the project | System: Patients / cell line(s) / animal model | Highlighted lncRNA(s)/pathway(s)/target(s)/ partners/ interactions | Disease context/ implication for human disease | Main result(s) | Ref |
|---|---|---|---|---|---|---|
Vitamin digestion and absorption (soluble and non-soluble) | To identify differentially expressed lncRNAs and mRNAs, 375 gastric adenocarcinoma and 32 adjacent non-tumor tissues were selected from TCGA | Bioinformatics analysis of mRNA and lncRNA expression profiles of 375 gastric adenocarcinoma and 32 adjacent non-tumor tissues | [AC115619.1-APOA4 /APOB] [AP006216.2-APOA1/APOA4] HOTAIR C20orf166-AS1, PGM5-AS1, HOXC-AS3, HOXC-AS2 AC012531.1 | Gastric Cancer (GAC) | • HOXC-AS3 cis-regulated the homeobox transcription factor genes HOXC8, HOXC9, HOXC10, HOXC11, HOXC12 and HOXC13 • Six lncRNAs (HOTAIR, C20orf166-AS1, PGM5-AS1, HOXC-AS3, HOXC-AS2, and AC012531.1) showed excellent diagnostic value as biomarkers for GAC | [108] |
Vitamin digestion and absorption | RNA sequencing of Hu sheep liver (with and without heat stress) inferred 520 DE mRNAs and 22 DE lncRNAs | Liver tissue of Hu Sheep | DE mRNAs showed enrichment in particular pathways including vitamin digestion and absorption | Animal health (productivity & reproductive efficiency) | Lnc_001782, because of its potential cis-regulatory effect, may positively regulate APOA4 and APOA5, two genes that are its genomic neighbors | [109] |